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Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats

BACKGROUND: Multiple dose administration of antiepileptic drugs to cats presents a challenge for owners. Extended release levetiracetam (XRL) has once daily recommended dosing interval, but multiple dose administration of XRL has not been evaluated in cats. OBJECTIVE: Evaluate serum levetiracetam co...

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Autores principales: Barnes Heller, Heidi, Granick, Martin, Van Hesteren, Mathew, Boothe, Dawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980453/
https://www.ncbi.nlm.nih.gov/pubmed/29671898
http://dx.doi.org/10.1111/jvim.15129
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author Barnes Heller, Heidi
Granick, Martin
Van Hesteren, Mathew
Boothe, Dawn M.
author_facet Barnes Heller, Heidi
Granick, Martin
Van Hesteren, Mathew
Boothe, Dawn M.
author_sort Barnes Heller, Heidi
collection PubMed
description BACKGROUND: Multiple dose administration of antiepileptic drugs to cats presents a challenge for owners. Extended release levetiracetam (XRL) has once daily recommended dosing interval, but multiple dose administration of XRL has not been evaluated in cats. OBJECTIVE: Evaluate serum levetiracetam concentrations and adverse clinical effects after 11 days of once daily XRL administration to healthy cats. ANIMALS: Nine healthy privately owned cats, body weight ≥ 5 kg METHODS: Extended release levetiracetam (500 mg/cat) was administered PO q24h for 10 days. On day 11, blood was collected at trough, 4, 6, and 8 hours after tablet administration. Owners maintained records of adverse effects throughout study. Levetiracetam was quantitated in serum using immunoassay validated in cats. RESULTS: Median dose 94.3 mg/kg q24h. Median (range) trough, 4, 6, and 8 hour serum levetiracetam concentrations were 7.0 (2.3‐14.1), 82.6 (7.8‐125.3), 92.3 (13.3‐97.3), and 72 (22.8‐96.4) μg/mL, respectively. Peak was not observed in 4 cats because of missed samples (n = 2) and failure to reach maximal concentration (C (max)) by 8 hours (n = 2). Median time of maximal concentration (T (max)) for the remaining 5 cats 5.2 (range 4‐6) hours. Adverse effects were minimal and included ataxia (n = 1), sedation (n = 1), and vomiting or regurgitation (n = 1). All signs resolved without dose adjustment or additional treatment. CONCLUSIONS AND CLINICAL IMPORTANCE: Mean trough serum levetiracetam concentrations were ≥5 μg/mL and adverse effects were minimal throughout dosing period, indicating that the drug was well tolerated. Once daily XRL (500 mg/cat) administration may provide an easier alternative to 3 times daily dosing of intermediate‐release levetiracetam for epileptic cats.
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spelling pubmed-59804532018-06-06 Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats Barnes Heller, Heidi Granick, Martin Van Hesteren, Mathew Boothe, Dawn M. J Vet Intern Med SMALL ANIMAL BACKGROUND: Multiple dose administration of antiepileptic drugs to cats presents a challenge for owners. Extended release levetiracetam (XRL) has once daily recommended dosing interval, but multiple dose administration of XRL has not been evaluated in cats. OBJECTIVE: Evaluate serum levetiracetam concentrations and adverse clinical effects after 11 days of once daily XRL administration to healthy cats. ANIMALS: Nine healthy privately owned cats, body weight ≥ 5 kg METHODS: Extended release levetiracetam (500 mg/cat) was administered PO q24h for 10 days. On day 11, blood was collected at trough, 4, 6, and 8 hours after tablet administration. Owners maintained records of adverse effects throughout study. Levetiracetam was quantitated in serum using immunoassay validated in cats. RESULTS: Median dose 94.3 mg/kg q24h. Median (range) trough, 4, 6, and 8 hour serum levetiracetam concentrations were 7.0 (2.3‐14.1), 82.6 (7.8‐125.3), 92.3 (13.3‐97.3), and 72 (22.8‐96.4) μg/mL, respectively. Peak was not observed in 4 cats because of missed samples (n = 2) and failure to reach maximal concentration (C (max)) by 8 hours (n = 2). Median time of maximal concentration (T (max)) for the remaining 5 cats 5.2 (range 4‐6) hours. Adverse effects were minimal and included ataxia (n = 1), sedation (n = 1), and vomiting or regurgitation (n = 1). All signs resolved without dose adjustment or additional treatment. CONCLUSIONS AND CLINICAL IMPORTANCE: Mean trough serum levetiracetam concentrations were ≥5 μg/mL and adverse effects were minimal throughout dosing period, indicating that the drug was well tolerated. Once daily XRL (500 mg/cat) administration may provide an easier alternative to 3 times daily dosing of intermediate‐release levetiracetam for epileptic cats. John Wiley and Sons Inc. 2018-04-19 2018 /pmc/articles/PMC5980453/ /pubmed/29671898 http://dx.doi.org/10.1111/jvim.15129 Text en Copyright © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Barnes Heller, Heidi
Granick, Martin
Van Hesteren, Mathew
Boothe, Dawn M.
Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats
title Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats
title_full Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats
title_fullStr Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats
title_full_unstemmed Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats
title_short Serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats
title_sort serum levetiracetam concentrations and adverse events after multiple dose extended release levetiracetam administration to healthy cats
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980453/
https://www.ncbi.nlm.nih.gov/pubmed/29671898
http://dx.doi.org/10.1111/jvim.15129
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