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M‐type K(+) channels in peripheral nociceptive pathways

Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and controlled by a complement of ion channels it expresses, in order to understand and treat pain, we need to develop a mechanistic insight into the key ion channels controlling excitability within the mamm...

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Autores principales: Du, Xiaona, Gao, Haixia, Jaffe, David, Zhang, Hailin, Gamper, Nikita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980636/
https://www.ncbi.nlm.nih.gov/pubmed/28800673
http://dx.doi.org/10.1111/bph.13978
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author Du, Xiaona
Gao, Haixia
Jaffe, David
Zhang, Hailin
Gamper, Nikita
author_facet Du, Xiaona
Gao, Haixia
Jaffe, David
Zhang, Hailin
Gamper, Nikita
author_sort Du, Xiaona
collection PubMed
description Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and controlled by a complement of ion channels it expresses, in order to understand and treat pain, we need to develop a mechanistic insight into the key ion channels controlling excitability within the mammalian pain pathways and how these ion channels are regulated and modulated in various physiological and pathophysiological settings. In this review, we will discuss the emerging data on the expression in pain pathways, functional role and modulation of a family of voltage‐gated K(+) channels called ‘M channels’ (KCNQ, K(v)7). M channels are increasingly recognized as important players in controlling pain signalling, especially within the peripheral somatosensory system. We will also discuss the therapeutic potential of M channels as analgesic drug targets. LINKED ARTICLES: This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc/
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spelling pubmed-59806362018-06-06 M‐type K(+) channels in peripheral nociceptive pathways Du, Xiaona Gao, Haixia Jaffe, David Zhang, Hailin Gamper, Nikita Br J Pharmacol Themed Section: Review Articles Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and controlled by a complement of ion channels it expresses, in order to understand and treat pain, we need to develop a mechanistic insight into the key ion channels controlling excitability within the mammalian pain pathways and how these ion channels are regulated and modulated in various physiological and pathophysiological settings. In this review, we will discuss the emerging data on the expression in pain pathways, functional role and modulation of a family of voltage‐gated K(+) channels called ‘M channels’ (KCNQ, K(v)7). M channels are increasingly recognized as important players in controlling pain signalling, especially within the peripheral somatosensory system. We will also discuss the therapeutic potential of M channels as analgesic drug targets. LINKED ARTICLES: This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc/ John Wiley and Sons Inc. 2017-09-17 2018-06 /pmc/articles/PMC5980636/ /pubmed/28800673 http://dx.doi.org/10.1111/bph.13978 Text en © 2017 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Themed Section: Review Articles
Du, Xiaona
Gao, Haixia
Jaffe, David
Zhang, Hailin
Gamper, Nikita
M‐type K(+) channels in peripheral nociceptive pathways
title M‐type K(+) channels in peripheral nociceptive pathways
title_full M‐type K(+) channels in peripheral nociceptive pathways
title_fullStr M‐type K(+) channels in peripheral nociceptive pathways
title_full_unstemmed M‐type K(+) channels in peripheral nociceptive pathways
title_short M‐type K(+) channels in peripheral nociceptive pathways
title_sort m‐type k(+) channels in peripheral nociceptive pathways
topic Themed Section: Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980636/
https://www.ncbi.nlm.nih.gov/pubmed/28800673
http://dx.doi.org/10.1111/bph.13978
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