Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long non-coding RNA 1) as an important long non-coding RNA...

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Detalles Bibliográficos
Autores principales: Zhang, Yajia, Pitchiaya, Sethuramasundaram, Cieślik, Marcin, Niknafs, Yashar S., Tien, Jean C-Y., Hosono, Yasuyuki, Iyer, Matthew K., Yazdani, Sahr, Subramaniam, Shruthi, Shukla, Sudhanshu K., Jiang, Xia, Wang, Lisha, Liu, Tzu-Ying, Uhl, Michael, Gawronski, Alexander R., Qiao, Yuanyuan, Xiao, Lanbo, Dhanasekaran, Saravana M., Juckette, Kristin M., Kunju, Lakshmi P., Cao, Xuhong, Patel, Utsav, Batish, Mona, Shukla, Girish C., Paulsen, Michelle T., Ljungman, Mats, Jiang, Hui, Mehra, Rohit, Backofen, Rolf, Sahinalp, Cenk S., Freier, Susan M., Watt, Andrew T., Guo, Shuling, Wei, John T., Feng, Felix Y., Malik, Rohit, Chinnaiyan, Arul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980762/
https://www.ncbi.nlm.nih.gov/pubmed/29808028
http://dx.doi.org/10.1038/s41588-018-0120-1
Descripción
Sumario:The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long non-coding RNA 1) as an important long non-coding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by AR protein, ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling, and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression, and identifies ARLNC1 as a novel therapeutic target.

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