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Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression
The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long non-coding RNA 1) as an important long non-coding RNA...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980762/ https://www.ncbi.nlm.nih.gov/pubmed/29808028 http://dx.doi.org/10.1038/s41588-018-0120-1 |
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| author | Zhang, Yajia Pitchiaya, Sethuramasundaram Cieślik, Marcin Niknafs, Yashar S. Tien, Jean C-Y. Hosono, Yasuyuki Iyer, Matthew K. Yazdani, Sahr Subramaniam, Shruthi Shukla, Sudhanshu K. Jiang, Xia Wang, Lisha Liu, Tzu-Ying Uhl, Michael Gawronski, Alexander R. Qiao, Yuanyuan Xiao, Lanbo Dhanasekaran, Saravana M. Juckette, Kristin M. Kunju, Lakshmi P. Cao, Xuhong Patel, Utsav Batish, Mona Shukla, Girish C. Paulsen, Michelle T. Ljungman, Mats Jiang, Hui Mehra, Rohit Backofen, Rolf Sahinalp, Cenk S. Freier, Susan M. Watt, Andrew T. Guo, Shuling Wei, John T. Feng, Felix Y. Malik, Rohit Chinnaiyan, Arul M. |
| author_facet | Zhang, Yajia Pitchiaya, Sethuramasundaram Cieślik, Marcin Niknafs, Yashar S. Tien, Jean C-Y. Hosono, Yasuyuki Iyer, Matthew K. Yazdani, Sahr Subramaniam, Shruthi Shukla, Sudhanshu K. Jiang, Xia Wang, Lisha Liu, Tzu-Ying Uhl, Michael Gawronski, Alexander R. Qiao, Yuanyuan Xiao, Lanbo Dhanasekaran, Saravana M. Juckette, Kristin M. Kunju, Lakshmi P. Cao, Xuhong Patel, Utsav Batish, Mona Shukla, Girish C. Paulsen, Michelle T. Ljungman, Mats Jiang, Hui Mehra, Rohit Backofen, Rolf Sahinalp, Cenk S. Freier, Susan M. Watt, Andrew T. Guo, Shuling Wei, John T. Feng, Felix Y. Malik, Rohit Chinnaiyan, Arul M. |
| author_sort | Zhang, Yajia |
| collection | PubMed |
| description | The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long non-coding RNA 1) as an important long non-coding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by AR protein, ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling, and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression, and identifies ARLNC1 as a novel therapeutic target. |
| format | Online Article Text |
| id | pubmed-5980762 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59807622018-11-28 Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression Zhang, Yajia Pitchiaya, Sethuramasundaram Cieślik, Marcin Niknafs, Yashar S. Tien, Jean C-Y. Hosono, Yasuyuki Iyer, Matthew K. Yazdani, Sahr Subramaniam, Shruthi Shukla, Sudhanshu K. Jiang, Xia Wang, Lisha Liu, Tzu-Ying Uhl, Michael Gawronski, Alexander R. Qiao, Yuanyuan Xiao, Lanbo Dhanasekaran, Saravana M. Juckette, Kristin M. Kunju, Lakshmi P. Cao, Xuhong Patel, Utsav Batish, Mona Shukla, Girish C. Paulsen, Michelle T. Ljungman, Mats Jiang, Hui Mehra, Rohit Backofen, Rolf Sahinalp, Cenk S. Freier, Susan M. Watt, Andrew T. Guo, Shuling Wei, John T. Feng, Felix Y. Malik, Rohit Chinnaiyan, Arul M. Nat Genet Article The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long non-coding RNA 1) as an important long non-coding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by AR protein, ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling, and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression, and identifies ARLNC1 as a novel therapeutic target. 2018-05-28 2018-06 /pmc/articles/PMC5980762/ /pubmed/29808028 http://dx.doi.org/10.1038/s41588-018-0120-1 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Zhang, Yajia Pitchiaya, Sethuramasundaram Cieślik, Marcin Niknafs, Yashar S. Tien, Jean C-Y. Hosono, Yasuyuki Iyer, Matthew K. Yazdani, Sahr Subramaniam, Shruthi Shukla, Sudhanshu K. Jiang, Xia Wang, Lisha Liu, Tzu-Ying Uhl, Michael Gawronski, Alexander R. Qiao, Yuanyuan Xiao, Lanbo Dhanasekaran, Saravana M. Juckette, Kristin M. Kunju, Lakshmi P. Cao, Xuhong Patel, Utsav Batish, Mona Shukla, Girish C. Paulsen, Michelle T. Ljungman, Mats Jiang, Hui Mehra, Rohit Backofen, Rolf Sahinalp, Cenk S. Freier, Susan M. Watt, Andrew T. Guo, Shuling Wei, John T. Feng, Felix Y. Malik, Rohit Chinnaiyan, Arul M. Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression |
| title | Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression |
| title_full | Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression |
| title_fullStr | Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression |
| title_full_unstemmed | Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression |
| title_short | Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression |
| title_sort | analysis of the androgen receptor-regulated lncrna landscape identifies a role for arlnc1 in prostate cancer progression |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980762/ https://www.ncbi.nlm.nih.gov/pubmed/29808028 http://dx.doi.org/10.1038/s41588-018-0120-1 |
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