Cargando…

A genome-wide cross trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide single-nucleotide polymorphism (SNP) data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from the UK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Zhaozhong, Lee, Phil H., Chaffin, Mark D., Chung, Wonil, Loh, Po-Ru, Lu, Quan, Christiani, David C., Liang, Liming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980765/ https://www.ncbi.nlm.nih.gov/pubmed/29785011 http://dx.doi.org/10.1038/s41588-018-0121-0

Ejemplares similares

Shared genetic architecture of blood eosinophil counts and asthma in UK Biobank
por: Li, Boyang, et al.
Publicado: (2023)

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
por: Schoech, Armin P., et al.
Publicado: (2019)

Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes
por: Chung, Wonil, et al.
Publicado: (2019)

Shared genetic architecture between mental health and the brain functional connectome in the UK Biobank
por: Roelfs, Daniel, et al.
Publicado: (2023)

Fast and accurate long-range phasing in a UK Biobank cohort
por: Loh, Po-Ru, et al.
Publicado: (2016)

Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis
por: Zhu, Zhaozhong, et al.
Publicado: (2021)

Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank
por: Fürtjes, Anna E., et al.
Publicado: (2022)

Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria
por: Dickey, Amy K., et al.
Publicado: (2020)

Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma
por: Han, Xikun, et al.
Publicado: (2022)

Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses
por: Barton, Alison R., et al.
Publicado: (2021)

Relationships between estimated autozygosity and complex traits in the UK Biobank
por: Johnson, Emma C., et al.
Publicado: (2018)

Effects of pathogenic CNVs on physical traits in participants of the UK Biobank
por: Owen, David, et al.
Publicado: (2018)

Subsampling Technique to Estimate Variance Component for UK-Biobank Traits
por: Xu, Ting, et al.
Publicado: (2021)

Analysing electrocardiographic traits and predicting cardiac risk in UK biobank
por: Ramírez, Julia, et al.
Publicado: (2021)

Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets
por: Márquez-Luna, Carla, et al.
Publicado: (2021)

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
por: Jurgens, Sean J., et al.
Publicado: (2022)

Is asthma associated with COVID-19 infection? A UK Biobank analysis
por: Lodge, Caroline J., et al.
Publicado: (2021)

The influence of childhood asthma on adult height: evidence from the UK Biobank
por: Chen, Wenwen, et al.
Publicado: (2022)

Revealing the recent demographic history of Europe via haplotype sharing in the UK Biobank
por: Gilbert, Edmund, et al.
Publicado: (2022)

Functional architecture of low-frequency variants highlights strength of negative selection across coding and noncoding annotations
por: Gazal, Steven, et al.
Publicado: (2018)

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
por: Tanigawa, Yosuke, et al.
Publicado: (2019)

Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort
por: Nagpal, Sini, et al.
Publicado: (2022)

Neuroticism personality traits are linked to adverse cardiovascular phenotypes in the UK Biobank
por: Mahmood, Adil, et al.
Publicado: (2023)

The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank
por: Vosberg, Daniel E., et al.
Publicado: (2023)

Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank
por: Huang, Ying-Jhen, et al.
Publicado: (2022)

Evaluating the contribution of genetic and familial shared environment to common disease using the UK Biobank
por: Muñoz, María, et al.
Publicado: (2016)

Shared exposure liability of type 2 diabetes and other chronic conditions in the UK Biobank
por: He, Yixuan, et al.
Publicado: (2022)

The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study
por: Pei, Yu-Fang, et al.
Publicado: (2020)

Significant sparse polygenic risk scores across 813 traits in UK Biobank
por: Tanigawa, Yosuke, et al.
Publicado: (2022)

The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank
por: Stuart, Kelsey V., et al.
Publicado: (2023)

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
por: Valette, Kim, et al.
Publicado: (2021)

Investigating the influence of breastfeeding on asthma in children under 12 years old in the UK Biobank
por: Hou, Wenyan, et al.
Publicado: (2022)

Association of genetic risk and lifestyle with incident adult-onset asthma in the UK Biobank cohort
por: Liang, Huaying, et al.
Publicado: (2023)

Shared Genetic Architecture and Causal Relationship Between Asthma and Cardiovascular Diseases: A Large-Scale Cross-Trait Analysis
por: Zhou, Yi, et al.
Publicado: (2022)

Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology
por: Ahmed, Muktar, et al.
Publicado: (2022)

Intakes of major food groups in China and UK: results from 100,000 adults in the China Kadoorie biobank and UK biobank
por: Papier, Keren, et al.
Publicado: (2022)

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
por: Zengini, Eleni, et al.
Publicado: (2018)

Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank
por: Morris, Julia, et al.
Publicado: (2020)

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
por: Hormozdiari, Farhad, et al.
Publicado: (2018)

Membranous nephropathy in the UK Biobank
por: Hamilton, Patrick, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mpj64f1rti3l3o3gstsnmc9fbu