Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer

We herein report a case of immune-related colitis induced by the long-term use of nivolumab. A 62-year-old Japanese man was treated with nivolumab at 3 mg/kg every 2 weeks for advanced lung adenocarcinoma. The patient was admitted to our hospital due to non-bloody watery diarrhea after the 70th dose...

Descripción completa

Detalles Bibliográficos
Autores principales: Yasuda, Yuichiro, Urata, Yoshiko, Tohnai, Rie, Ito, Shoichi, Kawa, Yoshitaka, Kono, Yuko, Hattori, Yoshihiro, Tsuda, Masahiro, Sakuma, Toshiko, Negoro, Shunichi, Satouchi, Miyako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980808/
https://www.ncbi.nlm.nih.gov/pubmed/29279482
http://dx.doi.org/10.2169/internalmedicine.9230-17
Descripción
Sumario:We herein report a case of immune-related colitis induced by the long-term use of nivolumab. A 62-year-old Japanese man was treated with nivolumab at 3 mg/kg every 2 weeks for advanced lung adenocarcinoma. The patient was admitted to our hospital due to non-bloody watery diarrhea after the 70th dose of nivolumab. A biopsy specimen of the colon mucosa revealed evidence of colitis with cryptitis and crypt microabscesses. He was diagnosed with immune-related colitis and started on predonisolone 60 mg/day. Subsequently, his symptoms remarkably resolved. Consideration of immune-related adverse events up to several years after the initiation of nivolumab is important.

Ejemplares similares