Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer

We herein report a case of immune-related colitis induced by the long-term use of nivolumab. A 62-year-old Japanese man was treated with nivolumab at 3 mg/kg every 2 weeks for advanced lung adenocarcinoma. The patient was admitted to our hospital due to non-bloody watery diarrhea after the 70th dose...

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Autores principales: Yasuda, Yuichiro, Urata, Yoshiko, Tohnai, Rie, Ito, Shoichi, Kawa, Yoshitaka, Kono, Yuko, Hattori, Yoshihiro, Tsuda, Masahiro, Sakuma, Toshiko, Negoro, Shunichi, Satouchi, Miyako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980808/
https://www.ncbi.nlm.nih.gov/pubmed/29279482
http://dx.doi.org/10.2169/internalmedicine.9230-17
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author Yasuda, Yuichiro
Urata, Yoshiko
Tohnai, Rie
Ito, Shoichi
Kawa, Yoshitaka
Kono, Yuko
Hattori, Yoshihiro
Tsuda, Masahiro
Sakuma, Toshiko
Negoro, Shunichi
Satouchi, Miyako
author_facet Yasuda, Yuichiro
Urata, Yoshiko
Tohnai, Rie
Ito, Shoichi
Kawa, Yoshitaka
Kono, Yuko
Hattori, Yoshihiro
Tsuda, Masahiro
Sakuma, Toshiko
Negoro, Shunichi
Satouchi, Miyako
author_sort Yasuda, Yuichiro
collection PubMed
description We herein report a case of immune-related colitis induced by the long-term use of nivolumab. A 62-year-old Japanese man was treated with nivolumab at 3 mg/kg every 2 weeks for advanced lung adenocarcinoma. The patient was admitted to our hospital due to non-bloody watery diarrhea after the 70th dose of nivolumab. A biopsy specimen of the colon mucosa revealed evidence of colitis with cryptitis and crypt microabscesses. He was diagnosed with immune-related colitis and started on predonisolone 60 mg/day. Subsequently, his symptoms remarkably resolved. Consideration of immune-related adverse events up to several years after the initiation of nivolumab is important.
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spelling pubmed-59808082018-06-04 Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer Yasuda, Yuichiro Urata, Yoshiko Tohnai, Rie Ito, Shoichi Kawa, Yoshitaka Kono, Yuko Hattori, Yoshihiro Tsuda, Masahiro Sakuma, Toshiko Negoro, Shunichi Satouchi, Miyako Intern Med Case Report We herein report a case of immune-related colitis induced by the long-term use of nivolumab. A 62-year-old Japanese man was treated with nivolumab at 3 mg/kg every 2 weeks for advanced lung adenocarcinoma. The patient was admitted to our hospital due to non-bloody watery diarrhea after the 70th dose of nivolumab. A biopsy specimen of the colon mucosa revealed evidence of colitis with cryptitis and crypt microabscesses. He was diagnosed with immune-related colitis and started on predonisolone 60 mg/day. Subsequently, his symptoms remarkably resolved. Consideration of immune-related adverse events up to several years after the initiation of nivolumab is important. The Japanese Society of Internal Medicine 2017-12-27 2018-05-01 /pmc/articles/PMC5980808/ /pubmed/29279482 http://dx.doi.org/10.2169/internalmedicine.9230-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yasuda, Yuichiro
Urata, Yoshiko
Tohnai, Rie
Ito, Shoichi
Kawa, Yoshitaka
Kono, Yuko
Hattori, Yoshihiro
Tsuda, Masahiro
Sakuma, Toshiko
Negoro, Shunichi
Satouchi, Miyako
Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer
title Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer
title_full Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer
title_fullStr Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer
title_full_unstemmed Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer
title_short Immune-related Colitis Induced by the Long-term Use of Nivolumab in a Patient with Non-small Cell Lung Cancer
title_sort immune-related colitis induced by the long-term use of nivolumab in a patient with non-small cell lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980808/
https://www.ncbi.nlm.nih.gov/pubmed/29279482
http://dx.doi.org/10.2169/internalmedicine.9230-17
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