EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period

A 70-year-old woman with lymphadenopathy was admitted to hospital in 2008. Lymph node biopsy showed reactive lymphoid hyperplasia (RH) with monoclonal proliferation of Epstein-Barr virus (EBV). Her lymphadenopathy regressed without treatment. In 2014, the patient presented with nasal obstruction bec...

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Autores principales: Kunitomi, Akane, Hasegawa, Yuta, Asano, Naoko, Kato, Seiichi, Tokunaga, Takashi, Miyata, Yasuhiko, Iida, Hiroatsu, Nagai, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980812/
https://www.ncbi.nlm.nih.gov/pubmed/29279478
http://dx.doi.org/10.2169/internalmedicine.9112-17
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author Kunitomi, Akane
Hasegawa, Yuta
Asano, Naoko
Kato, Seiichi
Tokunaga, Takashi
Miyata, Yasuhiko
Iida, Hiroatsu
Nagai, Hirokazu
author_facet Kunitomi, Akane
Hasegawa, Yuta
Asano, Naoko
Kato, Seiichi
Tokunaga, Takashi
Miyata, Yasuhiko
Iida, Hiroatsu
Nagai, Hirokazu
author_sort Kunitomi, Akane
collection PubMed
description A 70-year-old woman with lymphadenopathy was admitted to hospital in 2008. Lymph node biopsy showed reactive lymphoid hyperplasia (RH) with monoclonal proliferation of Epstein-Barr virus (EBV). Her lymphadenopathy regressed without treatment. In 2014, the patient presented with nasal obstruction because of a left nasal mass. She was diagnosed with EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly based on the examination of a biopsy specimen of the mass. The IgH rearrangement in the specimens from the 2008 and the 2014 revealed that they were genetically identical. This is the first report of RH progressing to DLBCL, and suggests that EBV-positive B-cells in RH lymph nodes predict the evolution to DLBCL.
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spelling pubmed-59808122018-06-04 EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period Kunitomi, Akane Hasegawa, Yuta Asano, Naoko Kato, Seiichi Tokunaga, Takashi Miyata, Yasuhiko Iida, Hiroatsu Nagai, Hirokazu Intern Med Case Report A 70-year-old woman with lymphadenopathy was admitted to hospital in 2008. Lymph node biopsy showed reactive lymphoid hyperplasia (RH) with monoclonal proliferation of Epstein-Barr virus (EBV). Her lymphadenopathy regressed without treatment. In 2014, the patient presented with nasal obstruction because of a left nasal mass. She was diagnosed with EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly based on the examination of a biopsy specimen of the mass. The IgH rearrangement in the specimens from the 2008 and the 2014 revealed that they were genetically identical. This is the first report of RH progressing to DLBCL, and suggests that EBV-positive B-cells in RH lymph nodes predict the evolution to DLBCL. The Japanese Society of Internal Medicine 2017-12-27 2018-05-01 /pmc/articles/PMC5980812/ /pubmed/29279478 http://dx.doi.org/10.2169/internalmedicine.9112-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kunitomi, Akane
Hasegawa, Yuta
Asano, Naoko
Kato, Seiichi
Tokunaga, Takashi
Miyata, Yasuhiko
Iida, Hiroatsu
Nagai, Hirokazu
EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period
title EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period
title_full EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period
title_fullStr EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period
title_full_unstemmed EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period
title_short EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period
title_sort ebv-positive reactive hyperplasia progressed into ebv-positive diffuse large b-cell lymphoma of the elderly over a 6-year period
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980812/
https://www.ncbi.nlm.nih.gov/pubmed/29279478
http://dx.doi.org/10.2169/internalmedicine.9112-17
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