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Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting
BACKGROUND: Acute lymphoblastic leukemia (ALL) is one of the most common malignancies among children, characterized by mass production of leukemic blasts. Chemotherapy is the first step in routine treatment, although it may evoke considerable side effects. Matrine, an alkaloid extracted from a Chine...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980949/ https://www.ncbi.nlm.nih.gov/pubmed/29481011 http://dx.doi.org/10.22034/APJCP.2018.19.2.555 |
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author | Aghvami, Marjan Ebrahimi, Fatemeh Zarei, Mohammad Hadi Salimi, Ahmad Jaktaji, Razieh Pourahmad Pourahmad, Jalal |
author_facet | Aghvami, Marjan Ebrahimi, Fatemeh Zarei, Mohammad Hadi Salimi, Ahmad Jaktaji, Razieh Pourahmad Pourahmad, Jalal |
author_sort | Aghvami, Marjan |
collection | PubMed |
description | BACKGROUND: Acute lymphoblastic leukemia (ALL) is one of the most common malignancies among children, characterized by mass production of leukemic blasts. Chemotherapy is the first step in routine treatment, although it may evoke considerable side effects. Matrine, an alkaloid extracted from a Chinese herb, Sophora alopecuroides flavescens Ait, may be protective. Several investigations have indicated pro-apoptotic and anti-proliferative effects in a diverse range of cancer cells. METHODS: Matrine’s anti-cancer effects and associated mechanisms were assessed in human ALL B-lymphocytes, focusing on parameters of inflammatory change and apoptosis. RESULTS: Treatment of ALL B-lymphocytes with matrine augmented ROS generation, and caused mitochondrial swelling and a decline in mitochondrial membrane potential. Significant up-regulation of the pro-apoptotic protein Bax and down-regulation of the anti-apoptotic Bcl-2 were also noted. CONCLUSION: Our results suggest that matrine may be a potential anticancer agent. However, additional studies are needed to clarify involved mechanisms. |
format | Online Article Text |
id | pubmed-5980949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-59809492018-06-07 Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting Aghvami, Marjan Ebrahimi, Fatemeh Zarei, Mohammad Hadi Salimi, Ahmad Jaktaji, Razieh Pourahmad Pourahmad, Jalal Asian Pac J Cancer Prev Research Article BACKGROUND: Acute lymphoblastic leukemia (ALL) is one of the most common malignancies among children, characterized by mass production of leukemic blasts. Chemotherapy is the first step in routine treatment, although it may evoke considerable side effects. Matrine, an alkaloid extracted from a Chinese herb, Sophora alopecuroides flavescens Ait, may be protective. Several investigations have indicated pro-apoptotic and anti-proliferative effects in a diverse range of cancer cells. METHODS: Matrine’s anti-cancer effects and associated mechanisms were assessed in human ALL B-lymphocytes, focusing on parameters of inflammatory change and apoptosis. RESULTS: Treatment of ALL B-lymphocytes with matrine augmented ROS generation, and caused mitochondrial swelling and a decline in mitochondrial membrane potential. Significant up-regulation of the pro-apoptotic protein Bax and down-regulation of the anti-apoptotic Bcl-2 were also noted. CONCLUSION: Our results suggest that matrine may be a potential anticancer agent. However, additional studies are needed to clarify involved mechanisms. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC5980949/ /pubmed/29481011 http://dx.doi.org/10.22034/APJCP.2018.19.2.555 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Aghvami, Marjan Ebrahimi, Fatemeh Zarei, Mohammad Hadi Salimi, Ahmad Jaktaji, Razieh Pourahmad Pourahmad, Jalal Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting |
title | Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting |
title_full | Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting |
title_fullStr | Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting |
title_full_unstemmed | Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting |
title_short | Matrine Induction of ROS Mediated Apoptosis in Human ALL B-lymphocytes Via Mitochondrial Targeting |
title_sort | matrine induction of ros mediated apoptosis in human all b-lymphocytes via mitochondrial targeting |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980949/ https://www.ncbi.nlm.nih.gov/pubmed/29481011 http://dx.doi.org/10.22034/APJCP.2018.19.2.555 |
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