Cargando…

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

We have tested the effect of all 20 proteinogenic amino acids on the activity of the M2 isoenzyme of pyruvate kinase (M2PYK) and show that, within physiologically relevant concentrations, phenylalanine, alanine, tryptophan, methionine, valine, and proline act as inhibitors, while histidine and serin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Meng, McNae, Iain W., Chen, Yiyuan, Blackburn, Elizabeth A., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980995/ https://www.ncbi.nlm.nih.gov/pubmed/29748232 http://dx.doi.org/10.1042/BCJ20180171

Ejemplares similares

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies
por: Morgan, Hugh P., et al.
Publicado: (2014)

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
por: Mitchell, Alice Rose, et al.
Publicado: (2018)

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition
por: Yuan, Meng, et al.
Publicado: (2017)

Thermo‐kinetic analysis space expansion for cyclophilin‐ligand interactions – identification of a new nonpeptide inhibitor using Biacore™ T200
por: Wear, Martin A., et al.
Publicado: (2017)

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches
por: Fernandes, Peter M., et al.
Publicado: (2020)

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis
por: Fernandes, Peter M., et al.
Publicado: (2020)

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction
por: Fernandes, Peter M., et al.
Publicado: (2019)

A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using ÄKTAxpress(TM)
por: Nowicki, Matthew W., et al.
Publicado: (2015)

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
por: Zhong, Wenhe, et al.
Publicado: (2017)

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
por: McNae, Iain W., et al.
Publicado: (2021)

Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using ÄKTAxpress™
por: Ludwig, Cornelia, et al.
Publicado: (2010)

Development of the pyruvate kinase deficiency diary and pyruvate kinase deficiency impact assessment: Disease‐specific assessments
por: Salek, Sam, et al.
Publicado: (2020)

Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90
por: Blackburn, Elizabeth A., et al.
Publicado: (2015)

Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis
por: Bluemlein, Katharina, et al.
Publicado: (2012)

Allostatic load in the context of disasters
por: Sandifer, Paul A., et al.
Publicado: (2022)

Allostatic Load and Preterm Birth
por: Olson, David M., et al.
Publicado: (2015)

An engineered photoswitchable mammalian pyruvate kinase
por: Gehrig, Stefanie, et al.
Publicado: (2017)

Architectural Allostatic Overloading: Exploring a Connection between Architectural Form and Allostatic Overloading
por: Valentine, Cleo
Publicado: (2023)

Signaling by adenosine receptors—Homeostatic or allostatic control?
por: Cunha, Rodrigo A.
Publicado: (2019)

From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
por: Ullmann, Enrico, et al.
Publicado: (2019)

Lactate shuttling as an allostatic means of thermoregulation in the brain
por: Kane, Daniel A., et al.
Publicado: (2023)

A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A
por: Wear, Martin A., et al.
Publicado: (2005)

Psychometric validation of the Pyruvate Kinase Deficiency Diary and Pyruvate Kinase Deficiency Impact Assessment in adults in the phase 3 ACTIVATE trial
por: Andrae, David A., et al.
Publicado: (2023)

Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein–protein interactions by the MDM2 ligand nutlin‐3
por: Way, Luke, et al.
Publicado: (2016)

Elevated allostatic load early in the course of schizophrenia
por: Savransky, Anya, et al.
Publicado: (2018)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Molecular heterogeneity of pyruvate kinase deficiency
por: Bianchi, Paola, et al.
Publicado: (2020)

Pyruvate Kinase, Inflammation and Periodontal Disease
por: Grant, Melissa M.
Publicado: (2021)

Pyruvate Kinase Deficiency Causing Priapism
por: Shankar, Vinay Hanyalu, et al.
Publicado: (2023)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication
por: Horemans, Steff, et al.
Publicado: (2022)

A groundwork for allostatic neuro-education
por: Gerdes, Lee, et al.
Publicado: (2015)

Allostatic Load and Exposure Histories of Disadvantage
por: Prior, Lucy
Publicado: (2021)

Allostatic Load in Perimenopausal Women With Migraine
por: Alebna, Pamela, et al.
Publicado: (2021)

Allostatic load and risk of hearing impairment
por: Matthews, Katey, et al.
Publicado: (2022)

The energetic cost of allostasis and allostatic load
por: Bobba-Alves, Natalia, et al.
Publicado: (2022)

Pyruvate kinase deficiency in a newborn with extramedullary hematopoiesis in the skin
por: Voit, Richard A., et al.
Publicado: (2020)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l8umgrh02phjm067gb2tsc22tv