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An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

We have tested the effect of all 20 proteinogenic amino acids on the activity of the M2 isoenzyme of pyruvate kinase (M2PYK) and show that, within physiologically relevant concentrations, phenylalanine, alanine, tryptophan, methionine, valine, and proline act as inhibitors, while histidine and serin...

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Detalles Bibliográficos
Autores principales:	Yuan, Meng, McNae, Iain W., Chen, Yiyuan, Blackburn, Elizabeth A., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980995/ https://www.ncbi.nlm.nih.gov/pubmed/29748232 http://dx.doi.org/10.1042/BCJ20180171

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