Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry

GADD45β is selectively and constitutively expressed in Multiple Myeloma cells, and this expression correlates with an unfavourable clinical outcome. GADD45β physically interacts with the JNK kinase, MKK7, inhibiting its activity to enable the survival of cancer cells. DTP3 is a small peptide inhibit...

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Detalles Bibliográficos
Autores principales: Rega, Camilla, Russo, Rosita, Focà, Annalia, Sandomenico, Annamaria, Iaccarino, Emanuela, Raimondo, Domenico, Milanetti, Edoardo, Tornatore, Laura, Franzoso, Guido, Pedone, Paolo Vincenzo, Ruvo, Menotti, Chambery, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981002/
https://www.ncbi.nlm.nih.gov/pubmed/29572137
http://dx.doi.org/10.1016/j.ijbiomac.2018.03.090

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