Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

Activation of RAF kinase involves the association of its RAS-binding domain (RBD) and cysteine-rich domain (CRD) with membrane-anchored RAS. However, the overall architecture of the RAS/RBD/CRD ternary complex and the orientations of its constituent domains at the membrane remain unclear. Here, we h...

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Detalles Bibliográficos
Autores principales: Travers, Timothy, López, Cesar A., Van, Que N., Neale, Chris, Tonelli, Marco, Stephen, Andrew G., Gnanakaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981303/
https://www.ncbi.nlm.nih.gov/pubmed/29855542
http://dx.doi.org/10.1038/s41598-018-26832-4

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