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Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells

Mitochondrial mutations cause bioenergetic defects associated with failures to use the electron transfer chain and oxidize substrates. These defects are exacerbated under energetic stress conditions and ultimately cause cell deterioration and death. However, little is known about cellular strategies...

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Detalles Bibliográficos
Autores principales:	Soustek, Meghan S., Balsa, Eduardo, Barrow, Joeva J., Jedrychowski, Mark, Vogel, Rutger, Jan Smeitink, Gygi, Steve P., Puigserver, Pere
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981317/ https://www.ncbi.nlm.nih.gov/pubmed/29855477 http://dx.doi.org/10.1038/s41419-018-0696-5

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