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Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex

Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is t...

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Autores principales: Orekhova, Elena V., Sysoeva, Olga V., Schneiderman, Justin F., Lundström, Sebastian, Galuta, Ilia A., Goiaeva, Dzerasa E., Prokofyev, Andrey O., Riaz, Bushra, Keeler, Courtney, Hadjikhani, Nouchine, Gillberg, Christopher, Stroganova, Tatiana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981429/
https://www.ncbi.nlm.nih.gov/pubmed/29855596
http://dx.doi.org/10.1038/s41598-018-26779-6
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author Orekhova, Elena V.
Sysoeva, Olga V.
Schneiderman, Justin F.
Lundström, Sebastian
Galuta, Ilia A.
Goiaeva, Dzerasa E.
Prokofyev, Andrey O.
Riaz, Bushra
Keeler, Courtney
Hadjikhani, Nouchine
Gillberg, Christopher
Stroganova, Tatiana A.
author_facet Orekhova, Elena V.
Sysoeva, Olga V.
Schneiderman, Justin F.
Lundström, Sebastian
Galuta, Ilia A.
Goiaeva, Dzerasa E.
Prokofyev, Andrey O.
Riaz, Bushra
Keeler, Courtney
Hadjikhani, Nouchine
Gillberg, Christopher
Stroganova, Tatiana A.
author_sort Orekhova, Elena V.
collection PubMed
description Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sought to find a similar input-output relationship in humans with MEG via modulating the intensity of a visual stimulation by changing the velocity/temporal-frequency of visual motion. In the first experiment, adult participants observed static and moving gratings. The frequency of the MEG gamma response monotonically increased with motion velocity whereas power followed a bell-shape. In the second experiment, on a large group of children and adults, we found that despite drastic developmental changes in frequency and power of gamma oscillations, the relative suppression at high motion velocities was scaled to the same range of values across the life-span. In light of animal and modeling studies, the modulation of gamma power and frequency at high stimulation intensities characterizes the capacity of inhibitory neurons to counterbalance increasing excitation in visual networks. Gamma suppression may thus provide a non-invasive measure of inhibitory-based gain control in the healthy and diseased brain.
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spelling pubmed-59814292018-06-06 Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex Orekhova, Elena V. Sysoeva, Olga V. Schneiderman, Justin F. Lundström, Sebastian Galuta, Ilia A. Goiaeva, Dzerasa E. Prokofyev, Andrey O. Riaz, Bushra Keeler, Courtney Hadjikhani, Nouchine Gillberg, Christopher Stroganova, Tatiana A. Sci Rep Article Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sought to find a similar input-output relationship in humans with MEG via modulating the intensity of a visual stimulation by changing the velocity/temporal-frequency of visual motion. In the first experiment, adult participants observed static and moving gratings. The frequency of the MEG gamma response monotonically increased with motion velocity whereas power followed a bell-shape. In the second experiment, on a large group of children and adults, we found that despite drastic developmental changes in frequency and power of gamma oscillations, the relative suppression at high motion velocities was scaled to the same range of values across the life-span. In light of animal and modeling studies, the modulation of gamma power and frequency at high stimulation intensities characterizes the capacity of inhibitory neurons to counterbalance increasing excitation in visual networks. Gamma suppression may thus provide a non-invasive measure of inhibitory-based gain control in the healthy and diseased brain. Nature Publishing Group UK 2018-05-31 /pmc/articles/PMC5981429/ /pubmed/29855596 http://dx.doi.org/10.1038/s41598-018-26779-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Orekhova, Elena V.
Sysoeva, Olga V.
Schneiderman, Justin F.
Lundström, Sebastian
Galuta, Ilia A.
Goiaeva, Dzerasa E.
Prokofyev, Andrey O.
Riaz, Bushra
Keeler, Courtney
Hadjikhani, Nouchine
Gillberg, Christopher
Stroganova, Tatiana A.
Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex
title Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex
title_full Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex
title_fullStr Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex
title_full_unstemmed Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex
title_short Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex
title_sort input-dependent modulation of meg gamma oscillations reflects gain control in the visual cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981429/
https://www.ncbi.nlm.nih.gov/pubmed/29855596
http://dx.doi.org/10.1038/s41598-018-26779-6
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