A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo

Esophageal squamous cell carcinoma (ESCC) is a frequently diagnosed and deadly malignancy with few standard therapeutic options. Camptothecins are considered one of the most promising antitumor drugs. A modified lipophilic analog, gimatecan, was synthesized as a novel oral camptothecin and showed im...

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Detalles Bibliográficos
Autores principales: Zou, Jianling, Li, Shuang, Chen, Zuhua, Lu, Zhihao, Gao, Jing, Zou, Jianyin, Lin, Xiaoting, Li, Yanyan, Zhang, Cheng, Shen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981453/
https://www.ncbi.nlm.nih.gov/pubmed/29855512
http://dx.doi.org/10.1038/s41419-018-0700-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981453/
https://www.ncbi.nlm.nih.gov/pubmed/29855512
http://dx.doi.org/10.1038/s41419-018-0700-0

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