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Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma

This case represents the challenge and creativity necessary when treating patients with metastatic renal cell carcinoma who have been exposed to multiple lines of therapy. At present, treatment with immune checkpoint inhibition has stabilized and improved the metastatic disease of this patient with...

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Autores principales: Adashek, Jacob J., Salgia, Meghan, Dizman, Nazli, Kessler, Jonathan, Pal, Sumanta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981597/
https://www.ncbi.nlm.nih.gov/pubmed/29867435
http://dx.doi.org/10.1159/000489995
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author Adashek, Jacob J.
Salgia, Meghan
Dizman, Nazli
Kessler, Jonathan
Pal, Sumanta K.
author_facet Adashek, Jacob J.
Salgia, Meghan
Dizman, Nazli
Kessler, Jonathan
Pal, Sumanta K.
author_sort Adashek, Jacob J.
collection PubMed
description This case represents the challenge and creativity necessary when treating patients with metastatic renal cell carcinoma who have been exposed to multiple lines of therapy. At present, treatment with immune checkpoint inhibition has stabilized and improved the metastatic disease of this patient with the exception of hepatic lesions. This isolated progression within the liver led the employment of radioembolization, which successfully treated those metastases. This is the first documented case of metastatic renal cell carcinoma controlled with concurrent use of immune checkpoint inhibition and radioembolization for both extrahepatic and hepatic metastases, respectively. This case can be construed as a potential example of the abscopal effect and may provide the basis for understanding this type of response in select patients.
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spelling pubmed-59815972018-06-04 Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma Adashek, Jacob J. Salgia, Meghan Dizman, Nazli Kessler, Jonathan Pal, Sumanta K. Case Rep Oncol Case Report This case represents the challenge and creativity necessary when treating patients with metastatic renal cell carcinoma who have been exposed to multiple lines of therapy. At present, treatment with immune checkpoint inhibition has stabilized and improved the metastatic disease of this patient with the exception of hepatic lesions. This isolated progression within the liver led the employment of radioembolization, which successfully treated those metastases. This is the first documented case of metastatic renal cell carcinoma controlled with concurrent use of immune checkpoint inhibition and radioembolization for both extrahepatic and hepatic metastases, respectively. This case can be construed as a potential example of the abscopal effect and may provide the basis for understanding this type of response in select patients. S. Karger AG 2018-05-17 /pmc/articles/PMC5981597/ /pubmed/29867435 http://dx.doi.org/10.1159/000489995 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Adashek, Jacob J.
Salgia, Meghan
Dizman, Nazli
Kessler, Jonathan
Pal, Sumanta K.
Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma
title Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma
title_full Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma
title_fullStr Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma
title_full_unstemmed Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma
title_short Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma
title_sort concomitant radioembolization and immune checkpoint inhibition in metastatic renal cell carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981597/
https://www.ncbi.nlm.nih.gov/pubmed/29867435
http://dx.doi.org/10.1159/000489995
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