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Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network
Chemotherapy agents can cause serious adverse effects by attacking both cancer tissues and normal tissues. Therefore, we proposed a synthetic lethality (SL) concept-based computational method to identify specific anticancer drug targets. First, a 3-step screening strategy (network-based, frequency-b...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981615/ https://www.ncbi.nlm.nih.gov/pubmed/29855504 http://dx.doi.org/10.1038/s41598-018-26783-w |