Cargando…

Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population

Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research datab...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Shih-Yi, Hsu, Wu-Huei, Lin, Cheng-Li, Lin, Cheng-Chieh, Lin, Jane-Ming, Chang, Yun-Lun, Hsu, Chung-Y., Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981941/
https://www.ncbi.nlm.nih.gov/pubmed/29751509
http://dx.doi.org/10.3390/ijerph15050902
_version_ 1783328137102229504
author Lin, Shih-Yi
Hsu, Wu-Huei
Lin, Cheng-Li
Lin, Cheng-Chieh
Lin, Jane-Ming
Chang, Yun-Lun
Hsu, Chung-Y.
Kao, Chia-Hung
author_facet Lin, Shih-Yi
Hsu, Wu-Huei
Lin, Cheng-Li
Lin, Cheng-Chieh
Lin, Jane-Ming
Chang, Yun-Lun
Hsu, Chung-Y.
Kao, Chia-Hung
author_sort Lin, Shih-Yi
collection PubMed
description Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research database (NHIRD). We applied time-varying Cox proportional hazard models to assess the association between thyroid cancer and AMD. The multivariable models included conventional cardiovascular risk factors, myopia, vitreous floaters, hypothyroidism, hyperthyroidism, and treatment modality of thyroid cancer. The analysis process was stratified by age, gender, and comorbidity. In this study, 5253 patients were included in a thyroid cancer cohort (men 24.5%; median age 59.1 years (53.7–67.4 years), and 21,012 matched controls were included in a non-thyroid cancer cohort. The AMD incidence was 40.7 per 10,000 person/year in the thyroid cancer cohort. The thyroid cancer cohort had a higher risk (adjusted hazard ratio (aHR) = 1.38, 95% confidence interval, CI = 1.09–1.75) of AMD than the non-thyroid cohort. Thyroid cancer patients had a higher risk of AMD, especially the male patients (aHR = 1.92, 95% CI = 1.38–3.14) and the patients with comorbidities (aHR = 1.38, 95% CI = 1.09–1.74). In conclusion, thyroid cancer patients older than 50 years-old have increased risk of AMD.
format Online
Article
Text
id pubmed-5981941
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-59819412018-06-07 Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population Lin, Shih-Yi Hsu, Wu-Huei Lin, Cheng-Li Lin, Cheng-Chieh Lin, Jane-Ming Chang, Yun-Lun Hsu, Chung-Y. Kao, Chia-Hung Int J Environ Res Public Health Article Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research database (NHIRD). We applied time-varying Cox proportional hazard models to assess the association between thyroid cancer and AMD. The multivariable models included conventional cardiovascular risk factors, myopia, vitreous floaters, hypothyroidism, hyperthyroidism, and treatment modality of thyroid cancer. The analysis process was stratified by age, gender, and comorbidity. In this study, 5253 patients were included in a thyroid cancer cohort (men 24.5%; median age 59.1 years (53.7–67.4 years), and 21,012 matched controls were included in a non-thyroid cancer cohort. The AMD incidence was 40.7 per 10,000 person/year in the thyroid cancer cohort. The thyroid cancer cohort had a higher risk (adjusted hazard ratio (aHR) = 1.38, 95% confidence interval, CI = 1.09–1.75) of AMD than the non-thyroid cohort. Thyroid cancer patients had a higher risk of AMD, especially the male patients (aHR = 1.92, 95% CI = 1.38–3.14) and the patients with comorbidities (aHR = 1.38, 95% CI = 1.09–1.74). In conclusion, thyroid cancer patients older than 50 years-old have increased risk of AMD. MDPI 2018-05-03 2018-05 /pmc/articles/PMC5981941/ /pubmed/29751509 http://dx.doi.org/10.3390/ijerph15050902 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Shih-Yi
Hsu, Wu-Huei
Lin, Cheng-Li
Lin, Cheng-Chieh
Lin, Jane-Ming
Chang, Yun-Lun
Hsu, Chung-Y.
Kao, Chia-Hung
Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population
title Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population
title_full Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population
title_fullStr Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population
title_full_unstemmed Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population
title_short Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population
title_sort evidence for an association between macular degeneration and thyroid cancer in the aged population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981941/
https://www.ncbi.nlm.nih.gov/pubmed/29751509
http://dx.doi.org/10.3390/ijerph15050902
work_keys_str_mv AT linshihyi evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation
AT hsuwuhuei evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation
AT linchengli evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation
AT linchengchieh evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation
AT linjaneming evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation
AT changyunlun evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation
AT hsuchungy evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation
AT kaochiahung evidenceforanassociationbetweenmaculardegenerationandthyroidcancerintheagedpopulation