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Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population
Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research datab...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981941/ https://www.ncbi.nlm.nih.gov/pubmed/29751509 http://dx.doi.org/10.3390/ijerph15050902 |
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author | Lin, Shih-Yi Hsu, Wu-Huei Lin, Cheng-Li Lin, Cheng-Chieh Lin, Jane-Ming Chang, Yun-Lun Hsu, Chung-Y. Kao, Chia-Hung |
author_facet | Lin, Shih-Yi Hsu, Wu-Huei Lin, Cheng-Li Lin, Cheng-Chieh Lin, Jane-Ming Chang, Yun-Lun Hsu, Chung-Y. Kao, Chia-Hung |
author_sort | Lin, Shih-Yi |
collection | PubMed |
description | Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research database (NHIRD). We applied time-varying Cox proportional hazard models to assess the association between thyroid cancer and AMD. The multivariable models included conventional cardiovascular risk factors, myopia, vitreous floaters, hypothyroidism, hyperthyroidism, and treatment modality of thyroid cancer. The analysis process was stratified by age, gender, and comorbidity. In this study, 5253 patients were included in a thyroid cancer cohort (men 24.5%; median age 59.1 years (53.7–67.4 years), and 21,012 matched controls were included in a non-thyroid cancer cohort. The AMD incidence was 40.7 per 10,000 person/year in the thyroid cancer cohort. The thyroid cancer cohort had a higher risk (adjusted hazard ratio (aHR) = 1.38, 95% confidence interval, CI = 1.09–1.75) of AMD than the non-thyroid cohort. Thyroid cancer patients had a higher risk of AMD, especially the male patients (aHR = 1.92, 95% CI = 1.38–3.14) and the patients with comorbidities (aHR = 1.38, 95% CI = 1.09–1.74). In conclusion, thyroid cancer patients older than 50 years-old have increased risk of AMD. |
format | Online Article Text |
id | pubmed-5981941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59819412018-06-07 Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population Lin, Shih-Yi Hsu, Wu-Huei Lin, Cheng-Li Lin, Cheng-Chieh Lin, Jane-Ming Chang, Yun-Lun Hsu, Chung-Y. Kao, Chia-Hung Int J Environ Res Public Health Article Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research database (NHIRD). We applied time-varying Cox proportional hazard models to assess the association between thyroid cancer and AMD. The multivariable models included conventional cardiovascular risk factors, myopia, vitreous floaters, hypothyroidism, hyperthyroidism, and treatment modality of thyroid cancer. The analysis process was stratified by age, gender, and comorbidity. In this study, 5253 patients were included in a thyroid cancer cohort (men 24.5%; median age 59.1 years (53.7–67.4 years), and 21,012 matched controls were included in a non-thyroid cancer cohort. The AMD incidence was 40.7 per 10,000 person/year in the thyroid cancer cohort. The thyroid cancer cohort had a higher risk (adjusted hazard ratio (aHR) = 1.38, 95% confidence interval, CI = 1.09–1.75) of AMD than the non-thyroid cohort. Thyroid cancer patients had a higher risk of AMD, especially the male patients (aHR = 1.92, 95% CI = 1.38–3.14) and the patients with comorbidities (aHR = 1.38, 95% CI = 1.09–1.74). In conclusion, thyroid cancer patients older than 50 years-old have increased risk of AMD. MDPI 2018-05-03 2018-05 /pmc/articles/PMC5981941/ /pubmed/29751509 http://dx.doi.org/10.3390/ijerph15050902 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lin, Shih-Yi Hsu, Wu-Huei Lin, Cheng-Li Lin, Cheng-Chieh Lin, Jane-Ming Chang, Yun-Lun Hsu, Chung-Y. Kao, Chia-Hung Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population |
title | Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population |
title_full | Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population |
title_fullStr | Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population |
title_full_unstemmed | Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population |
title_short | Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population |
title_sort | evidence for an association between macular degeneration and thyroid cancer in the aged population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981941/ https://www.ncbi.nlm.nih.gov/pubmed/29751509 http://dx.doi.org/10.3390/ijerph15050902 |
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