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Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014)

Little information is available on the prevalences of birth defects in Korea. The aims of this study were to estimate recent prevalences of selected birth defects and to analyze the prevalence trends of these defects during the period from 2008 to 2014. Prevalences were calculated for 69 major birth...

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Autores principales: Ko, Jung-Keun, Lamichhane, Dirga Kumar, Kim, Hwan-Cheol, Leem, Jong-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981962/
https://www.ncbi.nlm.nih.gov/pubmed/29734759
http://dx.doi.org/10.3390/ijerph15050923
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author Ko, Jung-Keun
Lamichhane, Dirga Kumar
Kim, Hwan-Cheol
Leem, Jong-Han
author_facet Ko, Jung-Keun
Lamichhane, Dirga Kumar
Kim, Hwan-Cheol
Leem, Jong-Han
author_sort Ko, Jung-Keun
collection PubMed
description Little information is available on the prevalences of birth defects in Korea. The aims of this study were to estimate recent prevalences of selected birth defects and to analyze the prevalence trends of these defects during the period from 2008 to 2014. Prevalences were calculated for 69 major birth defects using health insurance claim data obtained from the Korea National Health Insurance Service (NHIS). Prevalence rate ratios were calculated using Poisson regression to analyze trends over the 7-year study period. The overall prevalence of a major birth defect was 446.3 per 10,000 births (95% CI: 444.0–448.6); 470.9 per 10,000 births (95% CI: 467.6–474.2) for males and 420.2 per 10,000 births (95% CI: 417–423.4) for females. The prevalence rates of the most common birth defects over the study period were; septal defect (138.2 per 10,000; 95% CI: 136.9–139.5), congenital hip dislocation (652 per 10,000; 95% CI: 64.1–65.9), and ventricular septal defect (62.62 per 10,000; 95% CI: 61.7–63.5). During the study period, a significant increase in the prevalence of a major birth defect was observed with a prevalence rate ratio (PRR) of 1.091. The strongest trend was observed for renal dysplasia, which had a PRR of 1.275 (95% CI: 1.211–1.343), and upward trends were observed for urogenital anomalies, such as, renal agenesis (PRR 1.102, 95% CI: 1.067–1.138), undescended testis (PRR 1.082, 95% CI: 1.072–1.093) and hypospadias (PRR 1.067, 95% CI: 1.044–1.090). This study shows an overall increase in the prevalences of birth defects, including hypospadias and undescended testis, which are known to be associated with endocrine factors. In the future, standardized birth defect registries should be established to enable these trends to be monitored.
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spelling pubmed-59819622018-06-07 Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014) Ko, Jung-Keun Lamichhane, Dirga Kumar Kim, Hwan-Cheol Leem, Jong-Han Int J Environ Res Public Health Article Little information is available on the prevalences of birth defects in Korea. The aims of this study were to estimate recent prevalences of selected birth defects and to analyze the prevalence trends of these defects during the period from 2008 to 2014. Prevalences were calculated for 69 major birth defects using health insurance claim data obtained from the Korea National Health Insurance Service (NHIS). Prevalence rate ratios were calculated using Poisson regression to analyze trends over the 7-year study period. The overall prevalence of a major birth defect was 446.3 per 10,000 births (95% CI: 444.0–448.6); 470.9 per 10,000 births (95% CI: 467.6–474.2) for males and 420.2 per 10,000 births (95% CI: 417–423.4) for females. The prevalence rates of the most common birth defects over the study period were; septal defect (138.2 per 10,000; 95% CI: 136.9–139.5), congenital hip dislocation (652 per 10,000; 95% CI: 64.1–65.9), and ventricular septal defect (62.62 per 10,000; 95% CI: 61.7–63.5). During the study period, a significant increase in the prevalence of a major birth defect was observed with a prevalence rate ratio (PRR) of 1.091. The strongest trend was observed for renal dysplasia, which had a PRR of 1.275 (95% CI: 1.211–1.343), and upward trends were observed for urogenital anomalies, such as, renal agenesis (PRR 1.102, 95% CI: 1.067–1.138), undescended testis (PRR 1.082, 95% CI: 1.072–1.093) and hypospadias (PRR 1.067, 95% CI: 1.044–1.090). This study shows an overall increase in the prevalences of birth defects, including hypospadias and undescended testis, which are known to be associated with endocrine factors. In the future, standardized birth defect registries should be established to enable these trends to be monitored. MDPI 2018-05-05 2018-05 /pmc/articles/PMC5981962/ /pubmed/29734759 http://dx.doi.org/10.3390/ijerph15050923 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ko, Jung-Keun
Lamichhane, Dirga Kumar
Kim, Hwan-Cheol
Leem, Jong-Han
Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014)
title Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014)
title_full Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014)
title_fullStr Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014)
title_full_unstemmed Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014)
title_short Trends in the Prevalences of Selected Birth Defects in Korea (2008–2014)
title_sort trends in the prevalences of selected birth defects in korea (2008–2014)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981962/
https://www.ncbi.nlm.nih.gov/pubmed/29734759
http://dx.doi.org/10.3390/ijerph15050923
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