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Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women

Approximately 33% of normal-length (21–35 days) cycles have subclinical ovulatory disturbances and lack sufficient progesterone, although their normal length ensures enough estrogen. Subclinical ovulatory disturbances are related to significant premenopausal spine bone loss (−0.86%/year). Molimina,...

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Detalles Bibliográficos
Autores principales: Prior, Jerilynn C., Konishi, Chiaki, Hitchcock, Christine L., Kingwell, Elaine, Janssen, Patti, Cheung, Anthony P., Fairbrother, Nichole, Goshtasebi, Azita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982055/
https://www.ncbi.nlm.nih.gov/pubmed/29783630
http://dx.doi.org/10.3390/ijerph15051016
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author Prior, Jerilynn C.
Konishi, Chiaki
Hitchcock, Christine L.
Kingwell, Elaine
Janssen, Patti
Cheung, Anthony P.
Fairbrother, Nichole
Goshtasebi, Azita
author_facet Prior, Jerilynn C.
Konishi, Chiaki
Hitchcock, Christine L.
Kingwell, Elaine
Janssen, Patti
Cheung, Anthony P.
Fairbrother, Nichole
Goshtasebi, Azita
author_sort Prior, Jerilynn C.
collection PubMed
description Approximately 33% of normal-length (21–35 days) cycles have subclinical ovulatory disturbances and lack sufficient progesterone, although their normal length ensures enough estrogen. Subclinical ovulatory disturbances are related to significant premenopausal spine bone loss (−0.86%/year). Molimina, non-distressing premenstrual experiences, may detect ovulation within normal-length cycles. This prospective study assessed the relationship between molimina and ovulation. After 1-cycle of daily diary and first morning urine collections, women answered the Molimina Question (MQ): “Can you tell by the way you feel that your period is coming?” and were invited to share (a) predictive premenstrual experience(s). A 3-fold increase in follicular-luteal pregnanediol levels confirmed ovulation. In 610 spontaneously menstruating women (not on hormonal contraception, mean age 31.5 ± 5.3, menarche age 12.7 ± 1.5, cycle length [CL] 29 days, MQ positive in 89%), reported premenstrual experiences which included negative moods (62%), cramps (48%), bloating (39%), and front (26%) or axillary (25%) breast tenderness. Of 432 women with pregnanediol-documented cycles, 398 (92%) were ovulatory (CL: 29 ± 5) and 34 (8%) had ovulatory disturbances (CL: 32 ± 14). Women with/without ovulatory cycles were similar in parity, body mass index, smoking, dietary restraint and the MQ; ovulatory-disturbed cycles were longer. Molimina did not confirm ovulation. A non-invasive, inexpensive ovulation indicator is needed to prevent osteoporosis.
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spelling pubmed-59820552018-06-07 Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women Prior, Jerilynn C. Konishi, Chiaki Hitchcock, Christine L. Kingwell, Elaine Janssen, Patti Cheung, Anthony P. Fairbrother, Nichole Goshtasebi, Azita Int J Environ Res Public Health Article Approximately 33% of normal-length (21–35 days) cycles have subclinical ovulatory disturbances and lack sufficient progesterone, although their normal length ensures enough estrogen. Subclinical ovulatory disturbances are related to significant premenopausal spine bone loss (−0.86%/year). Molimina, non-distressing premenstrual experiences, may detect ovulation within normal-length cycles. This prospective study assessed the relationship between molimina and ovulation. After 1-cycle of daily diary and first morning urine collections, women answered the Molimina Question (MQ): “Can you tell by the way you feel that your period is coming?” and were invited to share (a) predictive premenstrual experience(s). A 3-fold increase in follicular-luteal pregnanediol levels confirmed ovulation. In 610 spontaneously menstruating women (not on hormonal contraception, mean age 31.5 ± 5.3, menarche age 12.7 ± 1.5, cycle length [CL] 29 days, MQ positive in 89%), reported premenstrual experiences which included negative moods (62%), cramps (48%), bloating (39%), and front (26%) or axillary (25%) breast tenderness. Of 432 women with pregnanediol-documented cycles, 398 (92%) were ovulatory (CL: 29 ± 5) and 34 (8%) had ovulatory disturbances (CL: 32 ± 14). Women with/without ovulatory cycles were similar in parity, body mass index, smoking, dietary restraint and the MQ; ovulatory-disturbed cycles were longer. Molimina did not confirm ovulation. A non-invasive, inexpensive ovulation indicator is needed to prevent osteoporosis. MDPI 2018-05-18 2018-05 /pmc/articles/PMC5982055/ /pubmed/29783630 http://dx.doi.org/10.3390/ijerph15051016 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prior, Jerilynn C.
Konishi, Chiaki
Hitchcock, Christine L.
Kingwell, Elaine
Janssen, Patti
Cheung, Anthony P.
Fairbrother, Nichole
Goshtasebi, Azita
Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women
title Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women
title_full Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women
title_fullStr Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women
title_full_unstemmed Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women
title_short Does Molimina Indicate Ovulation? Prospective Data in a Hormonally Documented Single-Cycle in Spontaneously Menstruating Women
title_sort does molimina indicate ovulation? prospective data in a hormonally documented single-cycle in spontaneously menstruating women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982055/
https://www.ncbi.nlm.nih.gov/pubmed/29783630
http://dx.doi.org/10.3390/ijerph15051016
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