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Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures

Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this te...

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Autores principales: Xia, Wenfeng, Kuniyil Ajith Singh, Mithun, Maneas, Efthymios, Sato, Naoto, Shigeta, Yusuke, Agano, Toshitaka, Ourselin, Sebastian, J. West, Simeon, E. Desjardins, Adrien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982119/
https://www.ncbi.nlm.nih.gov/pubmed/29724014
http://dx.doi.org/10.3390/s18051394
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author Xia, Wenfeng
Kuniyil Ajith Singh, Mithun
Maneas, Efthymios
Sato, Naoto
Shigeta, Yusuke
Agano, Toshitaka
Ourselin, Sebastian
J. West, Simeon
E. Desjardins, Adrien
author_facet Xia, Wenfeng
Kuniyil Ajith Singh, Mithun
Maneas, Efthymios
Sato, Naoto
Shigeta, Yusuke
Agano, Toshitaka
Ourselin, Sebastian
J. West, Simeon
E. Desjardins, Adrien
author_sort Xia, Wenfeng
collection PubMed
description Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this technology has often been limited by bulky and expensive excitation sources. In this work, we demonstrate the feasibility of guiding minimally invasive procedures using a dual-mode photoacoustic and ultrasound imaging system with excitation from compact arrays of light-emitting diodes (LEDs) at 850 nm. Three validation experiments were performed. First, clinical metal needles inserted into biological tissue were imaged. Second, the imaging depth of the system was characterized using a blood-vessel-mimicking phantom. Third, the superficial vasculature in human volunteers was imaged. It was found that photoacoustic imaging enabled needle visualization with signal-to-noise ratios that were 1.2 to 2.2 times higher than those obtained with ultrasound imaging, over insertion angles of 26 to 51 degrees. With the blood vessel mimicking phantom, the maximum imaging depth was 38 mm. The superficial vasculature of a human middle finger and a human wrist were clearly visualized in real-time. We conclude that the LED-based system is promising for guiding minimally invasive procedures with peripheral tissue targets.
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spelling pubmed-59821192018-06-05 Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures Xia, Wenfeng Kuniyil Ajith Singh, Mithun Maneas, Efthymios Sato, Naoto Shigeta, Yusuke Agano, Toshitaka Ourselin, Sebastian J. West, Simeon E. Desjardins, Adrien Sensors (Basel) Article Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this technology has often been limited by bulky and expensive excitation sources. In this work, we demonstrate the feasibility of guiding minimally invasive procedures using a dual-mode photoacoustic and ultrasound imaging system with excitation from compact arrays of light-emitting diodes (LEDs) at 850 nm. Three validation experiments were performed. First, clinical metal needles inserted into biological tissue were imaged. Second, the imaging depth of the system was characterized using a blood-vessel-mimicking phantom. Third, the superficial vasculature in human volunteers was imaged. It was found that photoacoustic imaging enabled needle visualization with signal-to-noise ratios that were 1.2 to 2.2 times higher than those obtained with ultrasound imaging, over insertion angles of 26 to 51 degrees. With the blood vessel mimicking phantom, the maximum imaging depth was 38 mm. The superficial vasculature of a human middle finger and a human wrist were clearly visualized in real-time. We conclude that the LED-based system is promising for guiding minimally invasive procedures with peripheral tissue targets. MDPI 2018-05-01 /pmc/articles/PMC5982119/ /pubmed/29724014 http://dx.doi.org/10.3390/s18051394 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xia, Wenfeng
Kuniyil Ajith Singh, Mithun
Maneas, Efthymios
Sato, Naoto
Shigeta, Yusuke
Agano, Toshitaka
Ourselin, Sebastian
J. West, Simeon
E. Desjardins, Adrien
Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
title Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
title_full Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
title_fullStr Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
title_full_unstemmed Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
title_short Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
title_sort handheld real-time led-based photoacoustic and ultrasound imaging system for accurate visualization of clinical metal needles and superficial vasculature to guide minimally invasive procedures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982119/
https://www.ncbi.nlm.nih.gov/pubmed/29724014
http://dx.doi.org/10.3390/s18051394
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