Cargando…
Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures
Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this te...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982119/ https://www.ncbi.nlm.nih.gov/pubmed/29724014 http://dx.doi.org/10.3390/s18051394 |
_version_ | 1783328175577628672 |
---|---|
author | Xia, Wenfeng Kuniyil Ajith Singh, Mithun Maneas, Efthymios Sato, Naoto Shigeta, Yusuke Agano, Toshitaka Ourselin, Sebastian J. West, Simeon E. Desjardins, Adrien |
author_facet | Xia, Wenfeng Kuniyil Ajith Singh, Mithun Maneas, Efthymios Sato, Naoto Shigeta, Yusuke Agano, Toshitaka Ourselin, Sebastian J. West, Simeon E. Desjardins, Adrien |
author_sort | Xia, Wenfeng |
collection | PubMed |
description | Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this technology has often been limited by bulky and expensive excitation sources. In this work, we demonstrate the feasibility of guiding minimally invasive procedures using a dual-mode photoacoustic and ultrasound imaging system with excitation from compact arrays of light-emitting diodes (LEDs) at 850 nm. Three validation experiments were performed. First, clinical metal needles inserted into biological tissue were imaged. Second, the imaging depth of the system was characterized using a blood-vessel-mimicking phantom. Third, the superficial vasculature in human volunteers was imaged. It was found that photoacoustic imaging enabled needle visualization with signal-to-noise ratios that were 1.2 to 2.2 times higher than those obtained with ultrasound imaging, over insertion angles of 26 to 51 degrees. With the blood vessel mimicking phantom, the maximum imaging depth was 38 mm. The superficial vasculature of a human middle finger and a human wrist were clearly visualized in real-time. We conclude that the LED-based system is promising for guiding minimally invasive procedures with peripheral tissue targets. |
format | Online Article Text |
id | pubmed-5982119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59821192018-06-05 Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures Xia, Wenfeng Kuniyil Ajith Singh, Mithun Maneas, Efthymios Sato, Naoto Shigeta, Yusuke Agano, Toshitaka Ourselin, Sebastian J. West, Simeon E. Desjardins, Adrien Sensors (Basel) Article Ultrasound imaging is widely used to guide minimally invasive procedures, but the visualization of the invasive medical device and the procedure’s target is often challenging. Photoacoustic imaging has shown great promise for guiding minimally invasive procedures, but clinical translation of this technology has often been limited by bulky and expensive excitation sources. In this work, we demonstrate the feasibility of guiding minimally invasive procedures using a dual-mode photoacoustic and ultrasound imaging system with excitation from compact arrays of light-emitting diodes (LEDs) at 850 nm. Three validation experiments were performed. First, clinical metal needles inserted into biological tissue were imaged. Second, the imaging depth of the system was characterized using a blood-vessel-mimicking phantom. Third, the superficial vasculature in human volunteers was imaged. It was found that photoacoustic imaging enabled needle visualization with signal-to-noise ratios that were 1.2 to 2.2 times higher than those obtained with ultrasound imaging, over insertion angles of 26 to 51 degrees. With the blood vessel mimicking phantom, the maximum imaging depth was 38 mm. The superficial vasculature of a human middle finger and a human wrist were clearly visualized in real-time. We conclude that the LED-based system is promising for guiding minimally invasive procedures with peripheral tissue targets. MDPI 2018-05-01 /pmc/articles/PMC5982119/ /pubmed/29724014 http://dx.doi.org/10.3390/s18051394 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Xia, Wenfeng Kuniyil Ajith Singh, Mithun Maneas, Efthymios Sato, Naoto Shigeta, Yusuke Agano, Toshitaka Ourselin, Sebastian J. West, Simeon E. Desjardins, Adrien Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures |
title | Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures |
title_full | Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures |
title_fullStr | Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures |
title_full_unstemmed | Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures |
title_short | Handheld Real-Time LED-Based Photoacoustic and Ultrasound Imaging System for Accurate Visualization of Clinical Metal Needles and Superficial Vasculature to Guide Minimally Invasive Procedures |
title_sort | handheld real-time led-based photoacoustic and ultrasound imaging system for accurate visualization of clinical metal needles and superficial vasculature to guide minimally invasive procedures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982119/ https://www.ncbi.nlm.nih.gov/pubmed/29724014 http://dx.doi.org/10.3390/s18051394 |
work_keys_str_mv | AT xiawenfeng handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT kuniyilajithsinghmithun handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT maneasefthymios handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT satonaoto handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT shigetayusuke handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT aganotoshitaka handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT ourselinsebastian handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT jwestsimeon handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures AT edesjardinsadrien handheldrealtimeledbasedphotoacousticandultrasoundimagingsystemforaccuratevisualizationofclinicalmetalneedlesandsuperficialvasculaturetoguideminimallyinvasiveprocedures |