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Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine

AIMS: Creatine buffers cellular adenosine triphosphate (ATP) via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosyn...

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Detalles Bibliográficos
Autores principales:	Faller, Kiterie M E, Atzler, Dorothee, McAndrew, Debra J, Zervou, Sevasti, Whittington, Hannah J, Simon, Jillian N, Aksentijevic, Dunja, ten Hove, Michiel, Choe, Chi-un, Isbrandt, Dirk, Casadei, Barbara, Schneider, Jurgen E, Neubauer, Stefan, Lygate, Craig A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982714/ https://www.ncbi.nlm.nih.gov/pubmed/29236952 http://dx.doi.org/10.1093/cvr/cvx242

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