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Policy Lessons From Quantitative Modeling of Leprosy
Recent mathematical and statistical modeling of leprosy incidence data provides estimates of the current undiagnosed population and projections of diagnosed cases, as well as ongoing transmission. Furthermore, modeling studies have been used to evaluate the effectiveness of proposed intervention str...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982730/ https://www.ncbi.nlm.nih.gov/pubmed/29860289 http://dx.doi.org/10.1093/cid/ciy005 |
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author | Medley, Graham F Blok, David J Crump, Ronald E Hollingsworth, T Déirdre Galvani, Alison P Ndeffo-Mbah, Martial L Porco, Travis C Richardus, Jan Hendrik |
author_facet | Medley, Graham F Blok, David J Crump, Ronald E Hollingsworth, T Déirdre Galvani, Alison P Ndeffo-Mbah, Martial L Porco, Travis C Richardus, Jan Hendrik |
author_sort | Medley, Graham F |
collection | PubMed |
description | Recent mathematical and statistical modeling of leprosy incidence data provides estimates of the current undiagnosed population and projections of diagnosed cases, as well as ongoing transmission. Furthermore, modeling studies have been used to evaluate the effectiveness of proposed intervention strategies, such as postleprosy exposure prophylaxis and novel diagnostics, relative to current approaches. Such modeling studies have revealed both a slow decline of new cases and a substantial pool of undiagnosed infections. These findings highlight the need for active case detection, particularly targeting leprosy foci, as well as for continued research into innovative accurate, rapid, and cost-effective diagnostics. As leprosy incidence continues to decline, targeted active case detection primarily in foci and connected areas will likely become increasingly important. |
format | Online Article Text |
id | pubmed-5982730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59827302018-06-06 Policy Lessons From Quantitative Modeling of Leprosy Medley, Graham F Blok, David J Crump, Ronald E Hollingsworth, T Déirdre Galvani, Alison P Ndeffo-Mbah, Martial L Porco, Travis C Richardus, Jan Hendrik Clin Infect Dis Supplement Articles Recent mathematical and statistical modeling of leprosy incidence data provides estimates of the current undiagnosed population and projections of diagnosed cases, as well as ongoing transmission. Furthermore, modeling studies have been used to evaluate the effectiveness of proposed intervention strategies, such as postleprosy exposure prophylaxis and novel diagnostics, relative to current approaches. Such modeling studies have revealed both a slow decline of new cases and a substantial pool of undiagnosed infections. These findings highlight the need for active case detection, particularly targeting leprosy foci, as well as for continued research into innovative accurate, rapid, and cost-effective diagnostics. As leprosy incidence continues to decline, targeted active case detection primarily in foci and connected areas will likely become increasingly important. Oxford University Press 2018-06-15 2018-06-01 /pmc/articles/PMC5982730/ /pubmed/29860289 http://dx.doi.org/10.1093/cid/ciy005 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Supplement Articles Medley, Graham F Blok, David J Crump, Ronald E Hollingsworth, T Déirdre Galvani, Alison P Ndeffo-Mbah, Martial L Porco, Travis C Richardus, Jan Hendrik Policy Lessons From Quantitative Modeling of Leprosy |
title | Policy Lessons From Quantitative Modeling of Leprosy |
title_full | Policy Lessons From Quantitative Modeling of Leprosy |
title_fullStr | Policy Lessons From Quantitative Modeling of Leprosy |
title_full_unstemmed | Policy Lessons From Quantitative Modeling of Leprosy |
title_short | Policy Lessons From Quantitative Modeling of Leprosy |
title_sort | policy lessons from quantitative modeling of leprosy |
topic | Supplement Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982730/ https://www.ncbi.nlm.nih.gov/pubmed/29860289 http://dx.doi.org/10.1093/cid/ciy005 |
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