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Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring

Prenatal maternal psychosocial stress might influence the development of childhood asthma. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress d...

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Autores principales: Magnus, Maria C, Wright, Rosalind J, Røysamb, Espen, Parr, Christine L, Karlstad, Øystein, Page, Christian M, Nafstad, Per, Håberg, Siri E, London, Stephanie J, Nystad, Wenche
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982733/
https://www.ncbi.nlm.nih.gov/pubmed/29244063
http://dx.doi.org/10.1093/aje/kwx366
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author Magnus, Maria C
Wright, Rosalind J
Røysamb, Espen
Parr, Christine L
Karlstad, Øystein
Page, Christian M
Nafstad, Per
Håberg, Siri E
London, Stephanie J
Nystad, Wenche
author_facet Magnus, Maria C
Wright, Rosalind J
Røysamb, Espen
Parr, Christine L
Karlstad, Øystein
Page, Christian M
Nafstad, Per
Håberg, Siri E
London, Stephanie J
Nystad, Wenche
author_sort Magnus, Maria C
collection PubMed
description Prenatal maternal psychosocial stress might influence the development of childhood asthma. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress during and after pregnancy with asthma at age 7 years in the Norwegian Mother and Child Cohort Study (n = 63,626; children born in 2000–2007). Measures of psychosocial stress included lifetime major depressive symptoms, current anxiety/depression symptoms, use of antidepressants, anxiolytics, and/or hypnotics, life satisfaction, relationship satisfaction, work stress, and social support. Childhood asthma was associated with maternal lifetime major depressive symptoms (adjusted relative risk (aRR) = 1.19, 95% confidence interval (CI): 1.09, 1.30), in addition to symptoms of anxiety/depression during pregnancy (aRR = 1.17, 95% CI: 1.06, 1.29) and 6 months after delivery (aRR = 1.17, 95% CI: 1.07, 1.28). Maternal negative life events during pregnancy (aRR = 1.10, 95% CI: 1.06, 1.13) and 6 months after delivery (aRR = 1.14, 95% CI: 1.11, 1.18) were also associated with asthma. These associations were not replicated when evaluated within sibling groups. There were no associations with paternal psychosocial stress. In conclusion, maternal anxiety/depression and negative life events were associated with offspring asthma, but this might be explained by unmeasured maternal background characteristics that remain stable across deliveries.
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spelling pubmed-59827332018-06-06 Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring Magnus, Maria C Wright, Rosalind J Røysamb, Espen Parr, Christine L Karlstad, Øystein Page, Christian M Nafstad, Per Håberg, Siri E London, Stephanie J Nystad, Wenche Am J Epidemiol Original Contributions Prenatal maternal psychosocial stress might influence the development of childhood asthma. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress during and after pregnancy with asthma at age 7 years in the Norwegian Mother and Child Cohort Study (n = 63,626; children born in 2000–2007). Measures of psychosocial stress included lifetime major depressive symptoms, current anxiety/depression symptoms, use of antidepressants, anxiolytics, and/or hypnotics, life satisfaction, relationship satisfaction, work stress, and social support. Childhood asthma was associated with maternal lifetime major depressive symptoms (adjusted relative risk (aRR) = 1.19, 95% confidence interval (CI): 1.09, 1.30), in addition to symptoms of anxiety/depression during pregnancy (aRR = 1.17, 95% CI: 1.06, 1.29) and 6 months after delivery (aRR = 1.17, 95% CI: 1.07, 1.28). Maternal negative life events during pregnancy (aRR = 1.10, 95% CI: 1.06, 1.13) and 6 months after delivery (aRR = 1.14, 95% CI: 1.11, 1.18) were also associated with asthma. These associations were not replicated when evaluated within sibling groups. There were no associations with paternal psychosocial stress. In conclusion, maternal anxiety/depression and negative life events were associated with offspring asthma, but this might be explained by unmeasured maternal background characteristics that remain stable across deliveries. Oxford University Press 2018-06 2017-12-13 /pmc/articles/PMC5982733/ /pubmed/29244063 http://dx.doi.org/10.1093/aje/kwx366 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Contributions
Magnus, Maria C
Wright, Rosalind J
Røysamb, Espen
Parr, Christine L
Karlstad, Øystein
Page, Christian M
Nafstad, Per
Håberg, Siri E
London, Stephanie J
Nystad, Wenche
Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring
title Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring
title_full Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring
title_fullStr Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring
title_full_unstemmed Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring
title_short Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring
title_sort association of maternal psychosocial stress with increased risk of asthma development in offspring
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982733/
https://www.ncbi.nlm.nih.gov/pubmed/29244063
http://dx.doi.org/10.1093/aje/kwx366
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