Cargando…
Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring
Prenatal maternal psychosocial stress might influence the development of childhood asthma. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress d...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982733/ https://www.ncbi.nlm.nih.gov/pubmed/29244063 http://dx.doi.org/10.1093/aje/kwx366 |
_version_ | 1783328299045355520 |
---|---|
author | Magnus, Maria C Wright, Rosalind J Røysamb, Espen Parr, Christine L Karlstad, Øystein Page, Christian M Nafstad, Per Håberg, Siri E London, Stephanie J Nystad, Wenche |
author_facet | Magnus, Maria C Wright, Rosalind J Røysamb, Espen Parr, Christine L Karlstad, Øystein Page, Christian M Nafstad, Per Håberg, Siri E London, Stephanie J Nystad, Wenche |
author_sort | Magnus, Maria C |
collection | PubMed |
description | Prenatal maternal psychosocial stress might influence the development of childhood asthma. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress during and after pregnancy with asthma at age 7 years in the Norwegian Mother and Child Cohort Study (n = 63,626; children born in 2000–2007). Measures of psychosocial stress included lifetime major depressive symptoms, current anxiety/depression symptoms, use of antidepressants, anxiolytics, and/or hypnotics, life satisfaction, relationship satisfaction, work stress, and social support. Childhood asthma was associated with maternal lifetime major depressive symptoms (adjusted relative risk (aRR) = 1.19, 95% confidence interval (CI): 1.09, 1.30), in addition to symptoms of anxiety/depression during pregnancy (aRR = 1.17, 95% CI: 1.06, 1.29) and 6 months after delivery (aRR = 1.17, 95% CI: 1.07, 1.28). Maternal negative life events during pregnancy (aRR = 1.10, 95% CI: 1.06, 1.13) and 6 months after delivery (aRR = 1.14, 95% CI: 1.11, 1.18) were also associated with asthma. These associations were not replicated when evaluated within sibling groups. There were no associations with paternal psychosocial stress. In conclusion, maternal anxiety/depression and negative life events were associated with offspring asthma, but this might be explained by unmeasured maternal background characteristics that remain stable across deliveries. |
format | Online Article Text |
id | pubmed-5982733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59827332018-06-06 Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring Magnus, Maria C Wright, Rosalind J Røysamb, Espen Parr, Christine L Karlstad, Øystein Page, Christian M Nafstad, Per Håberg, Siri E London, Stephanie J Nystad, Wenche Am J Epidemiol Original Contributions Prenatal maternal psychosocial stress might influence the development of childhood asthma. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress during and after pregnancy with asthma at age 7 years in the Norwegian Mother and Child Cohort Study (n = 63,626; children born in 2000–2007). Measures of psychosocial stress included lifetime major depressive symptoms, current anxiety/depression symptoms, use of antidepressants, anxiolytics, and/or hypnotics, life satisfaction, relationship satisfaction, work stress, and social support. Childhood asthma was associated with maternal lifetime major depressive symptoms (adjusted relative risk (aRR) = 1.19, 95% confidence interval (CI): 1.09, 1.30), in addition to symptoms of anxiety/depression during pregnancy (aRR = 1.17, 95% CI: 1.06, 1.29) and 6 months after delivery (aRR = 1.17, 95% CI: 1.07, 1.28). Maternal negative life events during pregnancy (aRR = 1.10, 95% CI: 1.06, 1.13) and 6 months after delivery (aRR = 1.14, 95% CI: 1.11, 1.18) were also associated with asthma. These associations were not replicated when evaluated within sibling groups. There were no associations with paternal psychosocial stress. In conclusion, maternal anxiety/depression and negative life events were associated with offspring asthma, but this might be explained by unmeasured maternal background characteristics that remain stable across deliveries. Oxford University Press 2018-06 2017-12-13 /pmc/articles/PMC5982733/ /pubmed/29244063 http://dx.doi.org/10.1093/aje/kwx366 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Contributions Magnus, Maria C Wright, Rosalind J Røysamb, Espen Parr, Christine L Karlstad, Øystein Page, Christian M Nafstad, Per Håberg, Siri E London, Stephanie J Nystad, Wenche Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring |
title | Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring |
title_full | Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring |
title_fullStr | Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring |
title_full_unstemmed | Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring |
title_short | Association of Maternal Psychosocial Stress With Increased Risk of Asthma Development in Offspring |
title_sort | association of maternal psychosocial stress with increased risk of asthma development in offspring |
topic | Original Contributions |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982733/ https://www.ncbi.nlm.nih.gov/pubmed/29244063 http://dx.doi.org/10.1093/aje/kwx366 |
work_keys_str_mv | AT magnusmariac associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT wrightrosalindj associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT røysambespen associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT parrchristinel associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT karlstadøystein associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT pagechristianm associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT nafstadper associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT habergsirie associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT londonstephaniej associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring AT nystadwenche associationofmaternalpsychosocialstresswithincreasedriskofasthmadevelopmentinoffspring |