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Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification
OBJECTIVES: To investigate whether elevated urinary HAI-1, EpCAM and EGFR are independent prognostic biomarkers within non-muscle-invasive bladder cancer (NMIBC) patients, and have utility for risk stratification to facilitate treatment decisions. RESULTS: After accounting for EAU risk group in NMIB...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982738/ https://www.ncbi.nlm.nih.gov/pubmed/29861867 http://dx.doi.org/10.18632/oncotarget.25397 |
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author | Snell, Kym I.E. Ward, Douglas G. Gordon, Naheema S. Goldsmith, James C. Sutton, Andrew J. Patel, Prashant James, Nicholas D. Zeegers, Maurice P. Cheng, K.K. Bryan, Richard T. |
author_facet | Snell, Kym I.E. Ward, Douglas G. Gordon, Naheema S. Goldsmith, James C. Sutton, Andrew J. Patel, Prashant James, Nicholas D. Zeegers, Maurice P. Cheng, K.K. Bryan, Richard T. |
author_sort | Snell, Kym I.E. |
collection | PubMed |
description | OBJECTIVES: To investigate whether elevated urinary HAI-1, EpCAM and EGFR are independent prognostic biomarkers within non-muscle-invasive bladder cancer (NMIBC) patients, and have utility for risk stratification to facilitate treatment decisions. RESULTS: After accounting for EAU risk group in NMIBC patients, the risk of BC-specific death was 2.14 times higher (95% CI: 1.08 to 4.24) if HAI-1 was elevated and 2.04 times higher (95% CI: 1.02 to 4.07) if EpCAM was elevated. The majority of events occurred in the high-risk NMIBC group and this is where the biggest difference is seen in the survival curves when plotted for EAU risk groups separately. In MIBC patients, being elevated for any of the three biomarkers was significantly associated with BC-specific mortality after accounting for other risk factors, HR = 4.30 (95% CI: 1.85 to 10.03). PATIENTS AND METHODS: Urinary levels of HAI-1, EpCAM and EGFR were measured by ELISA in 683 and 175 patients with newly-diagnosed NMIBC and MIBC, respectively, recruited to the Bladder Cancer Prognosis Programme. Associations between biomarkers and progression, BC-specific mortality and all-cause mortality were evaluated using univariable and multivariable Cox regression models, adjusted for European Association of Urology (EAU) NMIBC risk groups. The upper 25% of values for each biomarker within NMIBC patients were considered as elevated. Exploratory analyses in urine from MIBC patients were also undertaken. CONCLUSION: Urinary HAI-1 and EpCAM are prognostic biomarkers for NMIBC patients. These biomarkers have potential to guide treatment decisions for high-risk NMIBC patients. Further analyses are required to define the roles of HAI-1, EpCAM and EGFR in MIBC patients. |
format | Online Article Text |
id | pubmed-5982738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-59827382018-06-01 Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification Snell, Kym I.E. Ward, Douglas G. Gordon, Naheema S. Goldsmith, James C. Sutton, Andrew J. Patel, Prashant James, Nicholas D. Zeegers, Maurice P. Cheng, K.K. Bryan, Richard T. Oncotarget Research Paper OBJECTIVES: To investigate whether elevated urinary HAI-1, EpCAM and EGFR are independent prognostic biomarkers within non-muscle-invasive bladder cancer (NMIBC) patients, and have utility for risk stratification to facilitate treatment decisions. RESULTS: After accounting for EAU risk group in NMIBC patients, the risk of BC-specific death was 2.14 times higher (95% CI: 1.08 to 4.24) if HAI-1 was elevated and 2.04 times higher (95% CI: 1.02 to 4.07) if EpCAM was elevated. The majority of events occurred in the high-risk NMIBC group and this is where the biggest difference is seen in the survival curves when plotted for EAU risk groups separately. In MIBC patients, being elevated for any of the three biomarkers was significantly associated with BC-specific mortality after accounting for other risk factors, HR = 4.30 (95% CI: 1.85 to 10.03). PATIENTS AND METHODS: Urinary levels of HAI-1, EpCAM and EGFR were measured by ELISA in 683 and 175 patients with newly-diagnosed NMIBC and MIBC, respectively, recruited to the Bladder Cancer Prognosis Programme. Associations between biomarkers and progression, BC-specific mortality and all-cause mortality were evaluated using univariable and multivariable Cox regression models, adjusted for European Association of Urology (EAU) NMIBC risk groups. The upper 25% of values for each biomarker within NMIBC patients were considered as elevated. Exploratory analyses in urine from MIBC patients were also undertaken. CONCLUSION: Urinary HAI-1 and EpCAM are prognostic biomarkers for NMIBC patients. These biomarkers have potential to guide treatment decisions for high-risk NMIBC patients. Further analyses are required to define the roles of HAI-1, EpCAM and EGFR in MIBC patients. Impact Journals LLC 2018-05-18 /pmc/articles/PMC5982738/ /pubmed/29861867 http://dx.doi.org/10.18632/oncotarget.25397 Text en Copyright: © 2018 Snell et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Snell, Kym I.E. Ward, Douglas G. Gordon, Naheema S. Goldsmith, James C. Sutton, Andrew J. Patel, Prashant James, Nicholas D. Zeegers, Maurice P. Cheng, K.K. Bryan, Richard T. Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification |
title | Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification |
title_full | Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification |
title_fullStr | Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification |
title_full_unstemmed | Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification |
title_short | Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification |
title_sort | exploring the roles of urinary hai-1, epcam & egfr in bladder cancer prognosis & risk stratification |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982738/ https://www.ncbi.nlm.nih.gov/pubmed/29861867 http://dx.doi.org/10.18632/oncotarget.25397 |
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