PHLDA2 is a key oncogene-induced negative feedback inhibitor of EGFR/ErbB2 signaling via interference with AKT signaling

Pleckstrin homology-like domain family A member 2 (PHLDA2) is located within the tumor suppressor region of 11p15, and its expression is suppressed in several malignant tumor types. We recently identified PHLDA2 as a robustly induced, novel downstream target of oncogenic EGFR/ErbB2 signaling. In an...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoqi, Li, Guangyuan, Koul, Sanjay, Ohki, Rieko, Maurer, Matthew, Borczuk, Alain, Halmos, Balazs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982771/
https://www.ncbi.nlm.nih.gov/pubmed/29861842
http://dx.doi.org/10.18632/oncotarget.3674

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