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Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015

BACKGROUND: Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited. METHODS: Data were collected on IAE cases reported through the National Epidemiologic...

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Autores principales: Okuno, Hideo, Yahata, Yuichiro, Tanaka-Taya, Keiko, Arai, Satoru, Satoh, Hiroshi, Morino, Saeko, Shimada, Tomoe, Sunagawa, Tomimasa, Uyeki, Timothy M, Oishi, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982813/
https://www.ncbi.nlm.nih.gov/pubmed/29293894
http://dx.doi.org/10.1093/cid/cix1126
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author Okuno, Hideo
Yahata, Yuichiro
Tanaka-Taya, Keiko
Arai, Satoru
Satoh, Hiroshi
Morino, Saeko
Shimada, Tomoe
Sunagawa, Tomimasa
Uyeki, Timothy M
Oishi, Kazunori
author_facet Okuno, Hideo
Yahata, Yuichiro
Tanaka-Taya, Keiko
Arai, Satoru
Satoh, Hiroshi
Morino, Saeko
Shimada, Tomoe
Sunagawa, Tomimasa
Uyeki, Timothy M
Oishi, Kazunori
author_sort Okuno, Hideo
collection PubMed
description BACKGROUND: Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited. METHODS: Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes. RESULTS: Among 385 IAE cases, median age at diagnosis was 7 years (range, 0–90), and 283 (74%) were aged <18 years. Mean seasonal incidence of IAE cases among children and adults (aged ≥18 years) was 2.83 and 0.19 cases per 1000000 population, respectively. IAE incidence did not vary by predominant influenza A virus subtype. IAE frequency was highest in school-aged (5–12 years) children (38%), followed by children aged 2–4 years (21%) and adults aged 18–49 years (11%). The proportion of cases with seizures was more common in children. There were more cases with cerebrospinal fluid pleocytosis among adults than in children (P < .01), especially among those aged 18–49 (17%) and 50–64 (19%) years. Case fatality proportion was highest in those aged 40–64 (17%) and ≥65 (20%) years. CONCLUSIONS: We found differences in the clinical features of IAE between adults and children in Japan. Although IAE incidence was higher in children, mortality was higher in adults. Efforts are needed to prevent and improve survival of patients with IAE, especially in adults.
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spelling pubmed-59828132018-06-06 Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 Okuno, Hideo Yahata, Yuichiro Tanaka-Taya, Keiko Arai, Satoru Satoh, Hiroshi Morino, Saeko Shimada, Tomoe Sunagawa, Tomimasa Uyeki, Timothy M Oishi, Kazunori Clin Infect Dis Articles and Commentaries BACKGROUND: Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited. METHODS: Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes. RESULTS: Among 385 IAE cases, median age at diagnosis was 7 years (range, 0–90), and 283 (74%) were aged <18 years. Mean seasonal incidence of IAE cases among children and adults (aged ≥18 years) was 2.83 and 0.19 cases per 1000000 population, respectively. IAE incidence did not vary by predominant influenza A virus subtype. IAE frequency was highest in school-aged (5–12 years) children (38%), followed by children aged 2–4 years (21%) and adults aged 18–49 years (11%). The proportion of cases with seizures was more common in children. There were more cases with cerebrospinal fluid pleocytosis among adults than in children (P < .01), especially among those aged 18–49 (17%) and 50–64 (19%) years. Case fatality proportion was highest in those aged 40–64 (17%) and ≥65 (20%) years. CONCLUSIONS: We found differences in the clinical features of IAE between adults and children in Japan. Although IAE incidence was higher in children, mortality was higher in adults. Efforts are needed to prevent and improve survival of patients with IAE, especially in adults. Oxford University Press 2018-06-15 2017-12-26 /pmc/articles/PMC5982813/ /pubmed/29293894 http://dx.doi.org/10.1093/cid/cix1126 Text en © The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Articles and Commentaries
Okuno, Hideo
Yahata, Yuichiro
Tanaka-Taya, Keiko
Arai, Satoru
Satoh, Hiroshi
Morino, Saeko
Shimada, Tomoe
Sunagawa, Tomimasa
Uyeki, Timothy M
Oishi, Kazunori
Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015
title Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015
title_full Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015
title_fullStr Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015
title_full_unstemmed Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015
title_short Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015
title_sort characteristics and outcomes of influenza-associated encephalopathy cases among children and adults in japan, 2010–2015
topic Articles and Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982813/
https://www.ncbi.nlm.nih.gov/pubmed/29293894
http://dx.doi.org/10.1093/cid/cix1126
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