Cargando…
Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015
BACKGROUND: Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited. METHODS: Data were collected on IAE cases reported through the National Epidemiologic...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982813/ https://www.ncbi.nlm.nih.gov/pubmed/29293894 http://dx.doi.org/10.1093/cid/cix1126 |
_version_ | 1783328315005730816 |
---|---|
author | Okuno, Hideo Yahata, Yuichiro Tanaka-Taya, Keiko Arai, Satoru Satoh, Hiroshi Morino, Saeko Shimada, Tomoe Sunagawa, Tomimasa Uyeki, Timothy M Oishi, Kazunori |
author_facet | Okuno, Hideo Yahata, Yuichiro Tanaka-Taya, Keiko Arai, Satoru Satoh, Hiroshi Morino, Saeko Shimada, Tomoe Sunagawa, Tomimasa Uyeki, Timothy M Oishi, Kazunori |
author_sort | Okuno, Hideo |
collection | PubMed |
description | BACKGROUND: Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited. METHODS: Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes. RESULTS: Among 385 IAE cases, median age at diagnosis was 7 years (range, 0–90), and 283 (74%) were aged <18 years. Mean seasonal incidence of IAE cases among children and adults (aged ≥18 years) was 2.83 and 0.19 cases per 1000000 population, respectively. IAE incidence did not vary by predominant influenza A virus subtype. IAE frequency was highest in school-aged (5–12 years) children (38%), followed by children aged 2–4 years (21%) and adults aged 18–49 years (11%). The proportion of cases with seizures was more common in children. There were more cases with cerebrospinal fluid pleocytosis among adults than in children (P < .01), especially among those aged 18–49 (17%) and 50–64 (19%) years. Case fatality proportion was highest in those aged 40–64 (17%) and ≥65 (20%) years. CONCLUSIONS: We found differences in the clinical features of IAE between adults and children in Japan. Although IAE incidence was higher in children, mortality was higher in adults. Efforts are needed to prevent and improve survival of patients with IAE, especially in adults. |
format | Online Article Text |
id | pubmed-5982813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59828132018-06-06 Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 Okuno, Hideo Yahata, Yuichiro Tanaka-Taya, Keiko Arai, Satoru Satoh, Hiroshi Morino, Saeko Shimada, Tomoe Sunagawa, Tomimasa Uyeki, Timothy M Oishi, Kazunori Clin Infect Dis Articles and Commentaries BACKGROUND: Influenza-associated encephalopathy (IAE) can result in severe neurologic disease with high mortality. Most IAE cases are reported among children worldwide. Understanding of IAE among adults is limited. METHODS: Data were collected on IAE cases reported through the National Epidemiological Surveillance of Infectious Diseases database in Japan from 2010 through 2015. IAE cases were stratified by age category and analyzed using descriptive statistics to assess differences in characteristics and outcomes. RESULTS: Among 385 IAE cases, median age at diagnosis was 7 years (range, 0–90), and 283 (74%) were aged <18 years. Mean seasonal incidence of IAE cases among children and adults (aged ≥18 years) was 2.83 and 0.19 cases per 1000000 population, respectively. IAE incidence did not vary by predominant influenza A virus subtype. IAE frequency was highest in school-aged (5–12 years) children (38%), followed by children aged 2–4 years (21%) and adults aged 18–49 years (11%). The proportion of cases with seizures was more common in children. There were more cases with cerebrospinal fluid pleocytosis among adults than in children (P < .01), especially among those aged 18–49 (17%) and 50–64 (19%) years. Case fatality proportion was highest in those aged 40–64 (17%) and ≥65 (20%) years. CONCLUSIONS: We found differences in the clinical features of IAE between adults and children in Japan. Although IAE incidence was higher in children, mortality was higher in adults. Efforts are needed to prevent and improve survival of patients with IAE, especially in adults. Oxford University Press 2018-06-15 2017-12-26 /pmc/articles/PMC5982813/ /pubmed/29293894 http://dx.doi.org/10.1093/cid/cix1126 Text en © The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Articles and Commentaries Okuno, Hideo Yahata, Yuichiro Tanaka-Taya, Keiko Arai, Satoru Satoh, Hiroshi Morino, Saeko Shimada, Tomoe Sunagawa, Tomimasa Uyeki, Timothy M Oishi, Kazunori Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 |
title | Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 |
title_full | Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 |
title_fullStr | Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 |
title_full_unstemmed | Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 |
title_short | Characteristics and Outcomes of Influenza-Associated Encephalopathy Cases Among Children and Adults in Japan, 2010–2015 |
title_sort | characteristics and outcomes of influenza-associated encephalopathy cases among children and adults in japan, 2010–2015 |
topic | Articles and Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982813/ https://www.ncbi.nlm.nih.gov/pubmed/29293894 http://dx.doi.org/10.1093/cid/cix1126 |
work_keys_str_mv | AT okunohideo characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT yahatayuichiro characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT tanakatayakeiko characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT araisatoru characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT satohhiroshi characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT morinosaeko characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT shimadatomoe characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT sunagawatomimasa characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT uyekitimothym characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 AT oishikazunori characteristicsandoutcomesofinfluenzaassociatedencephalopathycasesamongchildrenandadultsinjapan20102015 |