Acid Sphingomyelinase Promotes Cellular Internalization of Clostridium perfringens Iota-Toxin

Clostridium perfringens iota-toxin is a binary actin-ADP-ribosylating toxin composed of the enzymatic component Ia and receptor binding component Ib. Ib binds to a cell surface receptor, forms Ib oligomer in lipid rafts, and associates with Ia. The Ia-Ib complex then internalizes by endocytosis. Her...

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Detalles Bibliográficos
Autores principales: Nagahama, Masahiro, Takehara, Masaya, Miyamoto, Kazuaki, Ishidoh, Kazumi, Kobayashi, Keiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983265/
https://www.ncbi.nlm.nih.gov/pubmed/29783772
http://dx.doi.org/10.3390/toxins10050209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983265/
https://www.ncbi.nlm.nih.gov/pubmed/29783772
http://dx.doi.org/10.3390/toxins10050209

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