Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric aci...

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Detalles Bibliográficos
Autores principales: El-Demerdash, Amr, Moriou, Céline, Toullec, Jordan, Besson, Marc, Soulet, Stéphanie, Schmitt, Nelly, Petek, Sylvain, Lecchini, David, Debitus, Cécile, Al-Mourabit, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983277/
https://www.ncbi.nlm.nih.gov/pubmed/29702602
http://dx.doi.org/10.3390/md16050146
Descripción
Sumario:Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC(50) values of 0.7 μM and 1.3 μM, respectively.

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