Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric aci...

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Autores principales: El-Demerdash, Amr, Moriou, Céline, Toullec, Jordan, Besson, Marc, Soulet, Stéphanie, Schmitt, Nelly, Petek, Sylvain, Lecchini, David, Debitus, Cécile, Al-Mourabit, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983277/
https://www.ncbi.nlm.nih.gov/pubmed/29702602
http://dx.doi.org/10.3390/md16050146
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author El-Demerdash, Amr
Moriou, Céline
Toullec, Jordan
Besson, Marc
Soulet, Stéphanie
Schmitt, Nelly
Petek, Sylvain
Lecchini, David
Debitus, Cécile
Al-Mourabit, Ali
author_facet El-Demerdash, Amr
Moriou, Céline
Toullec, Jordan
Besson, Marc
Soulet, Stéphanie
Schmitt, Nelly
Petek, Sylvain
Lecchini, David
Debitus, Cécile
Al-Mourabit, Ali
author_sort El-Demerdash, Amr
collection PubMed
description Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC(50) values of 0.7 μM and 1.3 μM, respectively.
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spelling pubmed-59832772018-06-06 Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis El-Demerdash, Amr Moriou, Céline Toullec, Jordan Besson, Marc Soulet, Stéphanie Schmitt, Nelly Petek, Sylvain Lecchini, David Debitus, Cécile Al-Mourabit, Ali Mar Drugs Article Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC(50) values of 0.7 μM and 1.3 μM, respectively. MDPI 2018-04-27 /pmc/articles/PMC5983277/ /pubmed/29702602 http://dx.doi.org/10.3390/md16050146 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
El-Demerdash, Amr
Moriou, Céline
Toullec, Jordan
Besson, Marc
Soulet, Stéphanie
Schmitt, Nelly
Petek, Sylvain
Lecchini, David
Debitus, Cécile
Al-Mourabit, Ali
Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
title Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
title_full Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
title_fullStr Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
title_full_unstemmed Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
title_short Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis
title_sort bioactive bromotyrosine-derived alkaloids from the polynesian sponge suberea ianthelliformis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983277/
https://www.ncbi.nlm.nih.gov/pubmed/29702602
http://dx.doi.org/10.3390/md16050146
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