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Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations
Voltage-gated sodium (Na(V)) channels generate and propagate action potentials in excitable cells, and several Na(V) subtypes have become important targets for pain management. The μ-conotoxins inhibit subtypes of the Na(V) with varied specificity but often lack of specificity to interested subtypes...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983284/ https://www.ncbi.nlm.nih.gov/pubmed/29735899 http://dx.doi.org/10.3390/md16050153 |