Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity,...

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Detalles Bibliográficos
Autores principales: Pariollaud, Marie, Gibbs, Julie E., Hopwood, Thomas W., Brown, Sheila, Begley, Nicola, Vonslow, Ryan, Poolman, Toryn, Guo, Baoqiang, Saer, Ben, Jones, D. Heulyn, Tellam, James P., Bresciani, Stefano, Tomkinson, Nicholas C.O., Wojno-Picon, Justyna, Cooper, Anthony W.J., Daniels, Dion A., Trump, Ryan P., Grant, Daniel, Zuercher, William, Willson, Timothy M., MacDonald, Andrew S., Bolognese, Brian, Podolin, Patricia L., Sanchez, Yolanda, Loudon, Andrew S.I., Ray, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983347/
https://www.ncbi.nlm.nih.gov/pubmed/29533925
http://dx.doi.org/10.1172/JCI93910

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