Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression

Major depressive disorder (MDD) is a common condition that afflicts the general population across a broad spectrum of ages and social backgrounds. The inflammatory hypothesis of depression posits that immune hyperactivation and dysregulated cytokine production are involved in depression. To investig...

Descripción completa

Detalles Bibliográficos
Autores principales: Zou, Wei, Feng, Renjie, Yang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983476/
https://www.ncbi.nlm.nih.gov/pubmed/29856741
http://dx.doi.org/10.1371/journal.pone.0197267
_version_ 1783328428564414464
author Zou, Wei
Feng, Renjie
Yang, Yuan
author_facet Zou, Wei
Feng, Renjie
Yang, Yuan
author_sort Zou, Wei
collection PubMed
description Major depressive disorder (MDD) is a common condition that afflicts the general population across a broad spectrum of ages and social backgrounds. The inflammatory hypothesis of depression posits that immune hyperactivation and dysregulated cytokine production are involved in depression. To investigate cytokine profiles in patients with MDD, we examined the levels of the pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α, and those of the anti-inflammatory cytokines IL-10 and transforming growth factor (TGF)-β1 in antidepressant drug-naïve patients with MDD. Compared to healthy controls, patients with MDD had significantly higher levels of IL-1β, IL-10, and TNF-α, but significantly lower levels of IL-8. There were no significant differences in the levels of IL-6 or TGF-β1. We found linear correlations between IL-1β, TNF-α, and IL-8, and the severity of depression, as well as between IL-8 and anxiety level in patients with comorbid anxiety disorder. In addition, higher IL-1β and TNF-α levels were associated with higher Hamilton Depression Rating Scale (HAMD) scores, while higher IL-8 levels were associated with lower HAMD and Hamilton Anxiety Rating Scale scores. Here we present evidence of changes in cytokine levels in antidepressant drug-naïve patients with MDD. Abnormal expression of inflammatory cytokines in patients with depression suggests that depression activates an inflammatory process. Immunological abnormalities may be involved in the pathophysiology of depression.
format Online
Article
Text
id pubmed-5983476
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-59834762018-06-17 Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression Zou, Wei Feng, Renjie Yang, Yuan PLoS One Research Article Major depressive disorder (MDD) is a common condition that afflicts the general population across a broad spectrum of ages and social backgrounds. The inflammatory hypothesis of depression posits that immune hyperactivation and dysregulated cytokine production are involved in depression. To investigate cytokine profiles in patients with MDD, we examined the levels of the pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α, and those of the anti-inflammatory cytokines IL-10 and transforming growth factor (TGF)-β1 in antidepressant drug-naïve patients with MDD. Compared to healthy controls, patients with MDD had significantly higher levels of IL-1β, IL-10, and TNF-α, but significantly lower levels of IL-8. There were no significant differences in the levels of IL-6 or TGF-β1. We found linear correlations between IL-1β, TNF-α, and IL-8, and the severity of depression, as well as between IL-8 and anxiety level in patients with comorbid anxiety disorder. In addition, higher IL-1β and TNF-α levels were associated with higher Hamilton Depression Rating Scale (HAMD) scores, while higher IL-8 levels were associated with lower HAMD and Hamilton Anxiety Rating Scale scores. Here we present evidence of changes in cytokine levels in antidepressant drug-naïve patients with MDD. Abnormal expression of inflammatory cytokines in patients with depression suggests that depression activates an inflammatory process. Immunological abnormalities may be involved in the pathophysiology of depression. Public Library of Science 2018-06-01 /pmc/articles/PMC5983476/ /pubmed/29856741 http://dx.doi.org/10.1371/journal.pone.0197267 Text en © 2018 Zou et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zou, Wei
Feng, Renjie
Yang, Yuan
Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
title Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
title_full Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
title_fullStr Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
title_full_unstemmed Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
title_short Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
title_sort changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983476/
https://www.ncbi.nlm.nih.gov/pubmed/29856741
http://dx.doi.org/10.1371/journal.pone.0197267
work_keys_str_mv AT zouwei changesintheserumlevelsofinflammatorycytokinesinantidepressantdrugnaivepatientswithmajordepression
AT fengrenjie changesintheserumlevelsofinflammatorycytokinesinantidepressantdrugnaivepatientswithmajordepression
AT yangyuan changesintheserumlevelsofinflammatorycytokinesinantidepressantdrugnaivepatientswithmajordepression