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New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation

Protein L-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the pcmt1 gene, catalyzes repair of abnormal L-isoaspartyl linkages in age-damaged proteins. Pcmt1 knockout mice exhibit a profound neuropathology and die 30–60 days postnatal from an epileptic seizure. Here we characterize four new...

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Detalles Bibliográficos
Autores principales:	Kim, Jeungjin, Chen, Baihe, Bru, Jean-Louis, Huynh, Eric, Momen, Mahsa, Aswad, Dana W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983485/ https://www.ncbi.nlm.nih.gov/pubmed/29856810 http://dx.doi.org/10.1371/journal.pone.0198266

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