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The smartphone camera as a potential method for transcutaneous bilirubin measurement
BACKGROUND: Hyperbilirubinemia is a common problem in neonates that can progress into kernicterus. Suspected neonatal hyperbilirubinemia is a common reason for contact with the healthcare system. The severity and management of jaundice are determined based on estimated bilirubin levels. However, no...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983497/ https://www.ncbi.nlm.nih.gov/pubmed/29856793 http://dx.doi.org/10.1371/journal.pone.0197938 |
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author | Munkholm, Sarah B. Krøgholt, Tobias Ebbesen, Finn Szecsi, Pal B. Kristensen, Søren R. |
author_facet | Munkholm, Sarah B. Krøgholt, Tobias Ebbesen, Finn Szecsi, Pal B. Kristensen, Søren R. |
author_sort | Munkholm, Sarah B. |
collection | PubMed |
description | BACKGROUND: Hyperbilirubinemia is a common problem in neonates that can progress into kernicterus. Suspected neonatal hyperbilirubinemia is a common reason for contact with the healthcare system. The severity and management of jaundice are determined based on estimated bilirubin levels. However, no easy and accessible tool for self-assessing neonatal jaundice is currently available. Smartphones could potentially be transformed into a medical device that could be used by both patients and practitioners. OBJECTIVE: To investigate whether a digital image produced by a camera embedded on a smartphone can be a used as a screening tool for neonatal hyperbilirubinemia. STUDY DESIGN: A total of 64 randomly selected newborns were enrolled. The inclusion criteria were healthy Caucasians, gestational age >35 weeks, age >24 hours and ≤14 days old, and parental informed consent. The exclusion criteria were facial skin lesions and light treatment. Images of the glabella were obtained with an iPhone 6 via i) directly applied pressure, ii) a dermatoscope, or iii) a dermatoscope equipped with a Wratten No. 11 filter. The red, green and blue colour intensities of each image were compared to bilirubin levels. RESULTS: Only the dermatoscope-acquired intensities of the green and blue channels were significantly correlated (p < 0.001) with bilirubin measurements (Pearson’s r: 0.59 and 0.48, respectively). For the green and blue channels, discrimination limits of 212 and 190, respectively, revealed a sensitivity and specificity of 100% and 62.5%, respectively, for green and 90.9% and 60%, respectively, for blue for a plasma bilirubin above 205 μmol/L. CONCLUSIONS: The results of this study indicate that a smartphone equipped with a consistent light source in the form of a dermatoscope may be a simple screening tool for neonatal hyperbilirubinemia. However, the method requires some improvement before clinical application. |
format | Online Article Text |
id | pubmed-5983497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59834972018-06-17 The smartphone camera as a potential method for transcutaneous bilirubin measurement Munkholm, Sarah B. Krøgholt, Tobias Ebbesen, Finn Szecsi, Pal B. Kristensen, Søren R. PLoS One Research Article BACKGROUND: Hyperbilirubinemia is a common problem in neonates that can progress into kernicterus. Suspected neonatal hyperbilirubinemia is a common reason for contact with the healthcare system. The severity and management of jaundice are determined based on estimated bilirubin levels. However, no easy and accessible tool for self-assessing neonatal jaundice is currently available. Smartphones could potentially be transformed into a medical device that could be used by both patients and practitioners. OBJECTIVE: To investigate whether a digital image produced by a camera embedded on a smartphone can be a used as a screening tool for neonatal hyperbilirubinemia. STUDY DESIGN: A total of 64 randomly selected newborns were enrolled. The inclusion criteria were healthy Caucasians, gestational age >35 weeks, age >24 hours and ≤14 days old, and parental informed consent. The exclusion criteria were facial skin lesions and light treatment. Images of the glabella were obtained with an iPhone 6 via i) directly applied pressure, ii) a dermatoscope, or iii) a dermatoscope equipped with a Wratten No. 11 filter. The red, green and blue colour intensities of each image were compared to bilirubin levels. RESULTS: Only the dermatoscope-acquired intensities of the green and blue channels were significantly correlated (p < 0.001) with bilirubin measurements (Pearson’s r: 0.59 and 0.48, respectively). For the green and blue channels, discrimination limits of 212 and 190, respectively, revealed a sensitivity and specificity of 100% and 62.5%, respectively, for green and 90.9% and 60%, respectively, for blue for a plasma bilirubin above 205 μmol/L. CONCLUSIONS: The results of this study indicate that a smartphone equipped with a consistent light source in the form of a dermatoscope may be a simple screening tool for neonatal hyperbilirubinemia. However, the method requires some improvement before clinical application. Public Library of Science 2018-06-01 /pmc/articles/PMC5983497/ /pubmed/29856793 http://dx.doi.org/10.1371/journal.pone.0197938 Text en © 2018 Munkholm et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Munkholm, Sarah B. Krøgholt, Tobias Ebbesen, Finn Szecsi, Pal B. Kristensen, Søren R. The smartphone camera as a potential method for transcutaneous bilirubin measurement |
title | The smartphone camera as a potential method for transcutaneous bilirubin measurement |
title_full | The smartphone camera as a potential method for transcutaneous bilirubin measurement |
title_fullStr | The smartphone camera as a potential method for transcutaneous bilirubin measurement |
title_full_unstemmed | The smartphone camera as a potential method for transcutaneous bilirubin measurement |
title_short | The smartphone camera as a potential method for transcutaneous bilirubin measurement |
title_sort | smartphone camera as a potential method for transcutaneous bilirubin measurement |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983497/ https://www.ncbi.nlm.nih.gov/pubmed/29856793 http://dx.doi.org/10.1371/journal.pone.0197938 |
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