The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir

OBJECTIVE: The present study aimed to reveal the factors associated with virologic failure in sofosbuvir and ledipasvir (SOF/LDV)-treated patients, and identify baseline NS5A or NS5B resistance-associated substitutions (RASs). METHODS: Four hundred ninety-three patients with Hepatitis C Virus (HCV)...

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Detalles Bibliográficos
Autores principales: Mawatari, Seiichi, Oda, Kohei, Tabu, Kazuaki, Ijuin, Sho, Kumagai, Kotaro, Fujisaki, Kunio, Hashiguchi, Masafumi, Inada, Yukiko, Uto, Hirofumi, Hiramine, Yasunari, Kure, Takeshi, Hori, Takeshi, Taniyama, Oki, Kasai, Ai, Tamai, Tsutomu, Moriuchi, Akihiro, Ido, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983500/
https://www.ncbi.nlm.nih.gov/pubmed/29856885
http://dx.doi.org/10.1371/journal.pone.0198642

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