Cargando…

The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review

Background: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators’ (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to deter...

Descripción completa

Detalles Bibliográficos
Autores principales: Petr, Miroslav, Stastny, Petr, Zajac, Adam, Tufano, James J., Maciejewska-Skrendo, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983571/
https://www.ncbi.nlm.nih.gov/pubmed/29762540
http://dx.doi.org/10.3390/ijms19051472
_version_ 1783328447887572992
author Petr, Miroslav
Stastny, Petr
Zajac, Adam
Tufano, James J.
Maciejewska-Skrendo, Agnieszka
author_facet Petr, Miroslav
Stastny, Petr
Zajac, Adam
Tufano, James J.
Maciejewska-Skrendo, Agnieszka
author_sort Petr, Miroslav
collection PubMed
description Background: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators’ (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators’ polymorphisms can predict the training response to specific training stimuli. Methods: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words. Results: All ten of the included studies were performed using aerobic training in general, sedentary or elderly populations from 21 to 75 years of age. The non-responders for aerobic training (VO(2)peak increase, slow muscle fiber increase and low-density lipoprotein decrease) are the carriers of PPARGC1A rs8192678 Ser/Ser. The negative responders for aerobic training (decrease in VO(2)peak) are carriers of the PPARD rs2267668 G allele. The negative responders for aerobic training (decreased glucose tolerance and insulin response) are subjects with the PPARG rs1801282 Pro/Pro genotype. The best responders to aerobic training are PPARGC1A rs8192678 Gly/Gly, PPARD rs1053049 TT, PPARD rs2267668 AA and PPARG rs1801282 Ala carriers. Conclusions: The human response for aerobic training is significantly influenced by PPARs’ gene polymorphism and their coactivators, where aerobic training can negatively influence glucose metabolism and VO(2)peak in some genetically-predisposed individuals.
format Online
Article
Text
id pubmed-5983571
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-59835712018-06-05 The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review Petr, Miroslav Stastny, Petr Zajac, Adam Tufano, James J. Maciejewska-Skrendo, Agnieszka Int J Mol Sci Review Background: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators’ (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators’ polymorphisms can predict the training response to specific training stimuli. Methods: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words. Results: All ten of the included studies were performed using aerobic training in general, sedentary or elderly populations from 21 to 75 years of age. The non-responders for aerobic training (VO(2)peak increase, slow muscle fiber increase and low-density lipoprotein decrease) are the carriers of PPARGC1A rs8192678 Ser/Ser. The negative responders for aerobic training (decrease in VO(2)peak) are carriers of the PPARD rs2267668 G allele. The negative responders for aerobic training (decreased glucose tolerance and insulin response) are subjects with the PPARG rs1801282 Pro/Pro genotype. The best responders to aerobic training are PPARGC1A rs8192678 Gly/Gly, PPARD rs1053049 TT, PPARD rs2267668 AA and PPARG rs1801282 Ala carriers. Conclusions: The human response for aerobic training is significantly influenced by PPARs’ gene polymorphism and their coactivators, where aerobic training can negatively influence glucose metabolism and VO(2)peak in some genetically-predisposed individuals. MDPI 2018-05-15 /pmc/articles/PMC5983571/ /pubmed/29762540 http://dx.doi.org/10.3390/ijms19051472 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Petr, Miroslav
Stastny, Petr
Zajac, Adam
Tufano, James J.
Maciejewska-Skrendo, Agnieszka
The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review
title The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review
title_full The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review
title_fullStr The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review
title_full_unstemmed The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review
title_short The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review
title_sort role of peroxisome proliferator-activated receptors and their transcriptional coactivators gene variations in human trainability: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983571/
https://www.ncbi.nlm.nih.gov/pubmed/29762540
http://dx.doi.org/10.3390/ijms19051472
work_keys_str_mv AT petrmiroslav theroleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT stastnypetr theroleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT zajacadam theroleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT tufanojamesj theroleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT maciejewskaskrendoagnieszka theroleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT petrmiroslav roleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT stastnypetr roleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT zajacadam roleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT tufanojamesj roleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview
AT maciejewskaskrendoagnieszka roleofperoxisomeproliferatoractivatedreceptorsandtheirtranscriptionalcoactivatorsgenevariationsinhumantrainabilityasystematicreview