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Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model

Neuropathic pain after spinal surgery, so-called failed back surgery syndrome, is a frequently observed common complication. One cause of the pain is scar tissue formation, observed as post-surgical epidural adhesions. These adhesions may compress surrounding spinal nerves, resulting in pain, even a...

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Autores principales: Kikuchi, Kiyoshi, Setoyama, Kentaro, Terashi, Takuto, Sumizono, Megumi, Tancharoen, Salunya, Otsuka, Shotaro, Takada, Seiya, Nakanishi, Kazuki, Ueda, Koki, Sakakima, Harutoshi, Kawahara, Ko-ichi, Maruyama, Ikuro, Hattori, Gohsuke, Morioka, Motohiro, Tanaka, Eiichiro, Uchikado, Hisaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983581/
https://www.ncbi.nlm.nih.gov/pubmed/29783695
http://dx.doi.org/10.3390/ijms19051513
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author Kikuchi, Kiyoshi
Setoyama, Kentaro
Terashi, Takuto
Sumizono, Megumi
Tancharoen, Salunya
Otsuka, Shotaro
Takada, Seiya
Nakanishi, Kazuki
Ueda, Koki
Sakakima, Harutoshi
Kawahara, Ko-ichi
Maruyama, Ikuro
Hattori, Gohsuke
Morioka, Motohiro
Tanaka, Eiichiro
Uchikado, Hisaaki
author_facet Kikuchi, Kiyoshi
Setoyama, Kentaro
Terashi, Takuto
Sumizono, Megumi
Tancharoen, Salunya
Otsuka, Shotaro
Takada, Seiya
Nakanishi, Kazuki
Ueda, Koki
Sakakima, Harutoshi
Kawahara, Ko-ichi
Maruyama, Ikuro
Hattori, Gohsuke
Morioka, Motohiro
Tanaka, Eiichiro
Uchikado, Hisaaki
author_sort Kikuchi, Kiyoshi
collection PubMed
description Neuropathic pain after spinal surgery, so-called failed back surgery syndrome, is a frequently observed common complication. One cause of the pain is scar tissue formation, observed as post-surgical epidural adhesions. These adhesions may compress surrounding spinal nerves, resulting in pain, even after successful spinal surgery. E8002 is an anti-adhesive membrane. In Japan, a clinical trial of E8002 is currently ongoing in patients undergoing abdominal surgery. However, animal experiments have not been performed for E8002 in spinal surgery. We assessed the anti-adhesive effect of E8002 in a rat laminectomy model. The dura matter was covered with an E8002 membrane or left uncovered as a control. Neurological evaluations and histopathological findings were compared at six weeks postoperatively. Histopathological analyses were performed by hematoxylin–eosin and aldehyde fuchsin-Masson Goldner staining. Three assessment areas were selected at the middle and margins of the laminectomy sites, and the numbers of fibroblasts and inflammatory cells were counted. Blinded histopathological evaluation revealed that adhesions and scar formation were reduced in the E8002 group compared with the control group. The E8002 group had significantly lower numbers of fibroblasts and inflammatory cells than the control group. The present results indicate that E8002 can prevent epidural scar adhesions after laminectomy.
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spelling pubmed-59835812018-06-05 Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model Kikuchi, Kiyoshi Setoyama, Kentaro Terashi, Takuto Sumizono, Megumi Tancharoen, Salunya Otsuka, Shotaro Takada, Seiya Nakanishi, Kazuki Ueda, Koki Sakakima, Harutoshi Kawahara, Ko-ichi Maruyama, Ikuro Hattori, Gohsuke Morioka, Motohiro Tanaka, Eiichiro Uchikado, Hisaaki Int J Mol Sci Communication Neuropathic pain after spinal surgery, so-called failed back surgery syndrome, is a frequently observed common complication. One cause of the pain is scar tissue formation, observed as post-surgical epidural adhesions. These adhesions may compress surrounding spinal nerves, resulting in pain, even after successful spinal surgery. E8002 is an anti-adhesive membrane. In Japan, a clinical trial of E8002 is currently ongoing in patients undergoing abdominal surgery. However, animal experiments have not been performed for E8002 in spinal surgery. We assessed the anti-adhesive effect of E8002 in a rat laminectomy model. The dura matter was covered with an E8002 membrane or left uncovered as a control. Neurological evaluations and histopathological findings were compared at six weeks postoperatively. Histopathological analyses were performed by hematoxylin–eosin and aldehyde fuchsin-Masson Goldner staining. Three assessment areas were selected at the middle and margins of the laminectomy sites, and the numbers of fibroblasts and inflammatory cells were counted. Blinded histopathological evaluation revealed that adhesions and scar formation were reduced in the E8002 group compared with the control group. The E8002 group had significantly lower numbers of fibroblasts and inflammatory cells than the control group. The present results indicate that E8002 can prevent epidural scar adhesions after laminectomy. MDPI 2018-05-18 /pmc/articles/PMC5983581/ /pubmed/29783695 http://dx.doi.org/10.3390/ijms19051513 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kikuchi, Kiyoshi
Setoyama, Kentaro
Terashi, Takuto
Sumizono, Megumi
Tancharoen, Salunya
Otsuka, Shotaro
Takada, Seiya
Nakanishi, Kazuki
Ueda, Koki
Sakakima, Harutoshi
Kawahara, Ko-ichi
Maruyama, Ikuro
Hattori, Gohsuke
Morioka, Motohiro
Tanaka, Eiichiro
Uchikado, Hisaaki
Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model
title Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model
title_full Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model
title_fullStr Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model
title_full_unstemmed Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model
title_short Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model
title_sort application of a novel anti-adhesive membrane, e8002, in a rat laminectomy model
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983581/
https://www.ncbi.nlm.nih.gov/pubmed/29783695
http://dx.doi.org/10.3390/ijms19051513
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