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Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to...

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Autores principales: Aasen, Trond, Johnstone, Scott, Vidal-Brime, Laia, Lynn, K. Sabrina, Koval, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983588/
https://www.ncbi.nlm.nih.gov/pubmed/29701678
http://dx.doi.org/10.3390/ijms19051296
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author Aasen, Trond
Johnstone, Scott
Vidal-Brime, Laia
Lynn, K. Sabrina
Koval, Michael
author_facet Aasen, Trond
Johnstone, Scott
Vidal-Brime, Laia
Lynn, K. Sabrina
Koval, Michael
author_sort Aasen, Trond
collection PubMed
description Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability, and function. Here, we summarize these key regulatory events, with emphasis on how these affect connexin multifunctionality in health and disease.
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spelling pubmed-59835882018-06-05 Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease Aasen, Trond Johnstone, Scott Vidal-Brime, Laia Lynn, K. Sabrina Koval, Michael Int J Mol Sci Review Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability, and function. Here, we summarize these key regulatory events, with emphasis on how these affect connexin multifunctionality in health and disease. MDPI 2018-04-26 /pmc/articles/PMC5983588/ /pubmed/29701678 http://dx.doi.org/10.3390/ijms19051296 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aasen, Trond
Johnstone, Scott
Vidal-Brime, Laia
Lynn, K. Sabrina
Koval, Michael
Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease
title Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease
title_full Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease
title_fullStr Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease
title_full_unstemmed Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease
title_short Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease
title_sort connexins: synthesis, post-translational modifications, and trafficking in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983588/
https://www.ncbi.nlm.nih.gov/pubmed/29701678
http://dx.doi.org/10.3390/ijms19051296
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