Cargando…

Combined Transcriptomics, Proteomics and Bioinformatics Identify Drug Targets in Spinal Cord Injury

Spinal cord injury (SCI) causes irreversible tissue damage and severe loss of neurological function. Currently, there are no approved treatments and very few therapeutic targets are under investigation. Here, we combined 4 high-throughput transcriptomics and proteomics datasets, 7 days and 8 weeks f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tica, Jure, Bradbury, Elizabeth J., Didangelos, Athanasios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983596/ https://www.ncbi.nlm.nih.gov/pubmed/29758010 http://dx.doi.org/10.3390/ijms19051461

Ejemplares similares

Comparative Transcriptomics of Rat and Axolotl After Spinal Cord Injury Dissects Differences and Similarities in Inflammatory and Matrix Remodeling Gene Expression Patterns
por: Tica, Jure, et al.
Publicado: (2018)

High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury
por: Didangelos, Athanasios, et al.
Publicado: (2016)

Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury
por: Burnside, Emily R, et al.
Publicado: (2018)

Proteomic and bioinformatic analyses of spinal cord injury-induced skeletal muscle atrophy in rats
por: WEI, ZHI-JIAN, et al.
Publicado: (2016)

The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes and Cellular Components for Spinal Cord Injury-Related Neuropathic Pain
por: Huang, Runzhi, et al.
Publicado: (2020)

Bioinformatics analysis of ferroptosis in spinal cord injury
por: Li, Jin-Ze, et al.
Publicado: (2022)

Spinal cord injury drives chronic brain changes
por: Jure, Ignacio, et al.
Publicado: (2017)

Gene modification after spinal cord injury: Mechanisms and therapeutics
por: Smith, George M., et al.
Publicado: (2022)

Inhibiting an inhibitor: a decoy to recover dexterity after spinal cord injury
por: Bradbury, Elizabeth J, et al.
Publicado: (2020)

Combination Drug Therapy for Pain following Chronic Spinal Cord Injury
por: Hama, Aldric, et al.
Publicado: (2012)

Identification of pivotal genes and pathways for spinal cord injury via bioinformatics analysis
por: Zhu, Zonghao, et al.
Publicado: (2017)

Moving beyond the glial scar for spinal cord repair
por: Bradbury, Elizabeth J., et al.
Publicado: (2019)

Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players
por: Martins, Isaura, et al.
Publicado: (2023)

Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury
por: Yao, Xin-Qiang, et al.
Publicado: (2022)

Bioinformatic Analysis of the Proteome in Exosomes Derived From Plasma: Exosomes Involved in Cholesterol Metabolism Process of Patients With Spinal Cord Injury in the Acute Phase
por: Wu, Chunshuai, et al.
Publicado: (2021)

Bioinformatics Genes and Pathway Analysis for Chronic Neuropathic Pain after Spinal Cord Injury
por: Zhang, Guan, et al.
Publicado: (2017)

Bioinformatics analysis of circulating miRNAs related to cancer following spinal cord injury
por: Lopes, Elisangela C.P., et al.
Publicado: (2019)

Bioinformatic analysis of the gene expression profile in muscle atrophy after spinal cord injury
por: Huang, Hui, et al.
Publicado: (2021)

Identification of Key eRNAs for Spinal Cord Injury by Integrated Multinomial Bioinformatics Analysis
por: Huang, Runzhi, et al.
Publicado: (2021)

Investigation of the blood proteome in response to spinal cord injury in rodent models
por: Hulme, Charlotte H., et al.
Publicado: (2021)

Parallel Metabolomic Profiling of Cerebrospinal Fluid, Plasma, and Spinal Cord to Identify Biomarkers for Spinal Cord Injury
por: Yang, Hua, et al.
Publicado: (2021)

Drug Discovery in Spinal Cord Injury With Ankylosing Spondylitis Identified by Text Mining and Biomedical Databases
por: Wang, Chenfeng, et al.
Publicado: (2022)

Integrated bioinformatics analysis identifies the effects of Sema3A/NRP1 signaling in oligodendrocytes after spinal cord injury in rats
por: Hu, Rong, et al.
Publicado: (2022)

Antibody profiling identifies novel antigenic targets in spinal cord injury patients
por: Palmers, Ilse, et al.
Publicado: (2016)

Comprehensive Proteomic Profiling of Pressure Ulcers in Patients with Spinal Cord Injury Identifies a Specific Protein Pattern of Pathology
por: Baldan-Martin, Montserrat, et al.
Publicado: (2020)

Exosomes combined with biomaterials in the treatment of spinal cord injury
por: Zhang, Xuanxuan, et al.
Publicado: (2023)

Further insight into molecular mechanism underlying thoracic spinal cord injury using bioinformatics methods
por: WANG, WEIGUO, et al.
Publicado: (2015)

Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury
por: Qin, Chuan, et al.
Publicado: (2019)

Bioinformatics analysis of the wheel treadmill test on motor function recovery after spinal cord injury
por: Wang, Qiu‐Lin, et al.
Publicado: (2021)

Proteomic Portraits Reveal Evolutionarily Conserved and Divergent Responses to Spinal Cord Injury
por: Skinnider, Michael A., et al.
Publicado: (2021)

Age-Dependent Modulation of Cortical Transcriptomes in Spinal Cord Injury and Repair
por: Jaerve, Anne, et al.
Publicado: (2012)

Temporal changes in the spinal cord transcriptome after peripheral nerve injury
por: Weng, Jian, et al.
Publicado: (2020)

Transcriptomic analysis of spinal cord regeneration after injury in Cynops orientalis
por: Wang, Di, et al.
Publicado: (2023)

Proteomics Characterization of Extracellular Space Components in the Human Aorta
por: Didangelos, Athanasios, et al.
Publicado: (2010)

Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells
por: Stangeland, Biljana, et al.
Publicado: (2015)

Transcriptome of rat subcortical white matter and spinal cord after spinal injury and cortical stimulation
por: Kondiles, Bethany R., et al.
Publicado: (2021)

SPINAL CORD INJURY
Publicado: (1969)

Injuries to the Spinal Cord
por: Boland, Frank K.
Publicado: (1912)

Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury
por: Huie, J. R., et al.
Publicado: (2021)

Transcriptome-Wide N6-Methyladenosine Methylome Alteration in the Rat Spinal Cord After Acute Traumatic Spinal Cord Injury
por: Yu, Jiangtao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gipbejunlue0vbrll16eeqdub9