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Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry
Sphingomyelin- and cholesterol- enriched membrane domains, commonly referred to as “rafts” play a crucial role in a large number of intra- and intercellular processes. Recent experiments suggest that not only the volumetric inhomogeneity of lipid distribution in rafts, but also the arrangement of th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983600/ https://www.ncbi.nlm.nih.gov/pubmed/29772704 http://dx.doi.org/10.3390/ijms19051483 |
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author | Molotkovsky, Rodion J. Alexandrova, Veronika V. Galimzyanov, Timur R. Jiménez-Munguía, Irene Pavlov, Konstantin V. Batishchev, Oleg V. Akimov, Sergey A. |
author_facet | Molotkovsky, Rodion J. Alexandrova, Veronika V. Galimzyanov, Timur R. Jiménez-Munguía, Irene Pavlov, Konstantin V. Batishchev, Oleg V. Akimov, Sergey A. |
author_sort | Molotkovsky, Rodion J. |
collection | PubMed |
description | Sphingomyelin- and cholesterol- enriched membrane domains, commonly referred to as “rafts” play a crucial role in a large number of intra- and intercellular processes. Recent experiments suggest that not only the volumetric inhomogeneity of lipid distribution in rafts, but also the arrangement of the 1D boundary between the raft and the surrounding membrane is important for the membrane-associated processes. The reason is that the boundary preferentially recruits different peptides, such as HIV (human immunodeficiency virus) fusion peptide. In the present work, we report a theoretical investigation of mechanisms of influence of the raft boundary arrangement upon virus-induced membrane fusion. We theoretically predict that the raft boundary can act as an attractor for viral fusion peptides, which preferentially distribute into the vicinity of the boundary, playing the role of ‘line active components’ of the membrane (‘linactants’). We have calculated the height of the fusion energy barrier and demonstrated that, in the case of fusion between HIV membrane and the target cell, presence of the raft boundary in the vicinity of the fusion site facilitates fusion. The results we obtained can be further generalized to be applicable to other enveloped viruses. |
format | Online Article Text |
id | pubmed-5983600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59836002018-06-05 Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry Molotkovsky, Rodion J. Alexandrova, Veronika V. Galimzyanov, Timur R. Jiménez-Munguía, Irene Pavlov, Konstantin V. Batishchev, Oleg V. Akimov, Sergey A. Int J Mol Sci Article Sphingomyelin- and cholesterol- enriched membrane domains, commonly referred to as “rafts” play a crucial role in a large number of intra- and intercellular processes. Recent experiments suggest that not only the volumetric inhomogeneity of lipid distribution in rafts, but also the arrangement of the 1D boundary between the raft and the surrounding membrane is important for the membrane-associated processes. The reason is that the boundary preferentially recruits different peptides, such as HIV (human immunodeficiency virus) fusion peptide. In the present work, we report a theoretical investigation of mechanisms of influence of the raft boundary arrangement upon virus-induced membrane fusion. We theoretically predict that the raft boundary can act as an attractor for viral fusion peptides, which preferentially distribute into the vicinity of the boundary, playing the role of ‘line active components’ of the membrane (‘linactants’). We have calculated the height of the fusion energy barrier and demonstrated that, in the case of fusion between HIV membrane and the target cell, presence of the raft boundary in the vicinity of the fusion site facilitates fusion. The results we obtained can be further generalized to be applicable to other enveloped viruses. MDPI 2018-05-16 /pmc/articles/PMC5983600/ /pubmed/29772704 http://dx.doi.org/10.3390/ijms19051483 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Molotkovsky, Rodion J. Alexandrova, Veronika V. Galimzyanov, Timur R. Jiménez-Munguía, Irene Pavlov, Konstantin V. Batishchev, Oleg V. Akimov, Sergey A. Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry |
title | Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry |
title_full | Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry |
title_fullStr | Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry |
title_full_unstemmed | Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry |
title_short | Lateral Membrane Heterogeneity Regulates Viral-Induced Membrane Fusion during HIV Entry |
title_sort | lateral membrane heterogeneity regulates viral-induced membrane fusion during hiv entry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983600/ https://www.ncbi.nlm.nih.gov/pubmed/29772704 http://dx.doi.org/10.3390/ijms19051483 |
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