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Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryon...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983605/ https://www.ncbi.nlm.nih.gov/pubmed/29789460 http://dx.doi.org/10.3390/ijms19051543 |
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author | Zeng, Chui-Mian Chen, Zhe Fu, Li |
author_facet | Zeng, Chui-Mian Chen, Zhe Fu, Li |
author_sort | Zeng, Chui-Mian |
collection | PubMed |
description | Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers. |
format | Online Article Text |
id | pubmed-5983605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59836052018-06-05 Frizzled Receptors as Potential Therapeutic Targets in Human Cancers Zeng, Chui-Mian Chen, Zhe Fu, Li Int J Mol Sci Review Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers. MDPI 2018-05-22 /pmc/articles/PMC5983605/ /pubmed/29789460 http://dx.doi.org/10.3390/ijms19051543 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zeng, Chui-Mian Chen, Zhe Fu, Li Frizzled Receptors as Potential Therapeutic Targets in Human Cancers |
title | Frizzled Receptors as Potential Therapeutic Targets in Human Cancers |
title_full | Frizzled Receptors as Potential Therapeutic Targets in Human Cancers |
title_fullStr | Frizzled Receptors as Potential Therapeutic Targets in Human Cancers |
title_full_unstemmed | Frizzled Receptors as Potential Therapeutic Targets in Human Cancers |
title_short | Frizzled Receptors as Potential Therapeutic Targets in Human Cancers |
title_sort | frizzled receptors as potential therapeutic targets in human cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983605/ https://www.ncbi.nlm.nih.gov/pubmed/29789460 http://dx.doi.org/10.3390/ijms19051543 |
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