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Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryon...

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Detalles Bibliográficos
Autores principales: Zeng, Chui-Mian, Chen, Zhe, Fu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983605/
https://www.ncbi.nlm.nih.gov/pubmed/29789460
http://dx.doi.org/10.3390/ijms19051543
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author Zeng, Chui-Mian
Chen, Zhe
Fu, Li
author_facet Zeng, Chui-Mian
Chen, Zhe
Fu, Li
author_sort Zeng, Chui-Mian
collection PubMed
description Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers.
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spelling pubmed-59836052018-06-05 Frizzled Receptors as Potential Therapeutic Targets in Human Cancers Zeng, Chui-Mian Chen, Zhe Fu, Li Int J Mol Sci Review Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers. MDPI 2018-05-22 /pmc/articles/PMC5983605/ /pubmed/29789460 http://dx.doi.org/10.3390/ijms19051543 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zeng, Chui-Mian
Chen, Zhe
Fu, Li
Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
title Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
title_full Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
title_fullStr Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
title_full_unstemmed Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
title_short Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
title_sort frizzled receptors as potential therapeutic targets in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983605/
https://www.ncbi.nlm.nih.gov/pubmed/29789460
http://dx.doi.org/10.3390/ijms19051543
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