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New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide

Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of deoxythymidine monophosphate (dTMP) and has been a primary target for cancer chemotherapy. Although the physical structure of TYMS and the molecular mechanisms of TYMS catalyzing the conversion of deoxyuridine monophosph...

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Detalles Bibliográficos
Autores principales:	Xie, Dan, Wang, Lulu, Xiao, Qi, Wu, Xiaoyan, Zhang, Lin, Yang, Qingkai, Wang, Lina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983622/ https://www.ncbi.nlm.nih.gov/pubmed/29735940 http://dx.doi.org/10.3390/ijms19051393

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