Cargando…
Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
In this study, we investigated the therapeutic potential and medical applications of Sparassis crispa (S. crispa) by conducting a systematic review of the existing literature and performing a meta-analysis. The original efficacy treatment of the mushroom extract is considered primarily and searched...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983641/ https://www.ncbi.nlm.nih.gov/pubmed/29772715 http://dx.doi.org/10.3390/ijms19051487 |
_version_ | 1783328464896524288 |
---|---|
author | Thi Nhu Ngoc, Le Oh, You-Kwan Lee, Young-Jong Lee, Young-Chul |
author_facet | Thi Nhu Ngoc, Le Oh, You-Kwan Lee, Young-Jong Lee, Young-Chul |
author_sort | Thi Nhu Ngoc, Le |
collection | PubMed |
description | In this study, we investigated the therapeutic potential and medical applications of Sparassis crispa (S. crispa) by conducting a systematic review of the existing literature and performing a meta-analysis. The original efficacy treatment of the mushroom extract is considered primarily and searched in electronic databases. A total of 623 articles were assessed, 33 randomized controlled experiments were included after the manual screening, and some papers, review articles, or editorials that did not contain data were excluded. A comparative standard means difference (SMD) and a funnel plot between control and S. crispa groups were used as parameters to demonstrate the beneficial effects of S. crispa for diabetes and cancer treatment, as well as anti-inflammatory, anti-fungal and antioxidant activities. The meta-analysis was carried out using Review Manager 5.1 software. Although for therapeutic diabetes there was heterogeneity in the subgroup analysis (I(2) = 91.9%), the overall results showed statistically significant SMDs in major symptoms that decreased serum insulin levels (SMD = 1.92, 95% CI (1.10, 2.75), I(2) = 0%), wound rates (SMD = 3.55 (2.56, 4.54), I(2) = 40%) and contributions to an increase in nutrient intake content (SMD = 0.32 (−0.15, 0.78), I(2) = 0%). Simultaneously, the study confirmed the utility of S. crispa treatment in terms of not only anti-cancer activity (reduction of tumor activity and survival of cancer cells I(2) = 42 and 34%, respectively) but also anti-inflammatory, anti-fungal and antioxidant activities (I(2) = 50, 44, and 10%, respectively). Our findings suggest that S. crispa extracts are useful for prevention and treatment of human diseases and might be the best candidates for future medicines. |
format | Online Article Text |
id | pubmed-5983641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59836412018-06-05 Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Thi Nhu Ngoc, Le Oh, You-Kwan Lee, Young-Jong Lee, Young-Chul Int J Mol Sci Article In this study, we investigated the therapeutic potential and medical applications of Sparassis crispa (S. crispa) by conducting a systematic review of the existing literature and performing a meta-analysis. The original efficacy treatment of the mushroom extract is considered primarily and searched in electronic databases. A total of 623 articles were assessed, 33 randomized controlled experiments were included after the manual screening, and some papers, review articles, or editorials that did not contain data were excluded. A comparative standard means difference (SMD) and a funnel plot between control and S. crispa groups were used as parameters to demonstrate the beneficial effects of S. crispa for diabetes and cancer treatment, as well as anti-inflammatory, anti-fungal and antioxidant activities. The meta-analysis was carried out using Review Manager 5.1 software. Although for therapeutic diabetes there was heterogeneity in the subgroup analysis (I(2) = 91.9%), the overall results showed statistically significant SMDs in major symptoms that decreased serum insulin levels (SMD = 1.92, 95% CI (1.10, 2.75), I(2) = 0%), wound rates (SMD = 3.55 (2.56, 4.54), I(2) = 40%) and contributions to an increase in nutrient intake content (SMD = 0.32 (−0.15, 0.78), I(2) = 0%). Simultaneously, the study confirmed the utility of S. crispa treatment in terms of not only anti-cancer activity (reduction of tumor activity and survival of cancer cells I(2) = 42 and 34%, respectively) but also anti-inflammatory, anti-fungal and antioxidant activities (I(2) = 50, 44, and 10%, respectively). Our findings suggest that S. crispa extracts are useful for prevention and treatment of human diseases and might be the best candidates for future medicines. MDPI 2018-05-16 /pmc/articles/PMC5983641/ /pubmed/29772715 http://dx.doi.org/10.3390/ijms19051487 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Thi Nhu Ngoc, Le Oh, You-Kwan Lee, Young-Jong Lee, Young-Chul Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title | Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_full | Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_fullStr | Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed | Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_short | Effects of Sparassis crispa in Medical Therapeutics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
title_sort | effects of sparassis crispa in medical therapeutics: a systematic review and meta-analysis of randomized controlled trials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983641/ https://www.ncbi.nlm.nih.gov/pubmed/29772715 http://dx.doi.org/10.3390/ijms19051487 |
work_keys_str_mv | AT thinhungocle effectsofsparassiscrispainmedicaltherapeuticsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT ohyoukwan effectsofsparassiscrispainmedicaltherapeuticsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT leeyoungjong effectsofsparassiscrispainmedicaltherapeuticsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT leeyoungchul effectsofsparassiscrispainmedicaltherapeuticsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |