A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells

Molecular chaperones are key components of the protein homeostasis system against protein misfolding and aggregation. It has been recently shown that these molecules can be rationally modified to have an enhanced activity against specific amyloidogenic substrates. The resulting molecular chaperone v...

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Detalles Bibliográficos
Autores principales: Bongiovanni, Marie Nicole, Aprile, Francesco Antonio, Sormanni, Pietro, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983706/
https://www.ncbi.nlm.nih.gov/pubmed/29757200
http://dx.doi.org/10.3390/ijms19051443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983706/
https://www.ncbi.nlm.nih.gov/pubmed/29757200
http://dx.doi.org/10.3390/ijms19051443

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