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High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

Fibroblast growth factor receptor 1 (FGFR1) is a plasma membrane protein that transmits signals from the extracellular environment, regulating cell homeostasis and function. Dysregulation of FGFR1 leads to the development of human cancers and noncancerous diseases. Numerous tumors overproduce FGFR1,...

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Detalles Bibliográficos
Autores principales:	Opaliński, Łukasz, Szymczyk, Jakub, Szczepara, Martyna, Kucińska, Marika, Krowarsch, Daniel, Zakrzewska, Małgorzata, Otlewski, Jacek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983756/ https://www.ncbi.nlm.nih.gov/pubmed/29748524 http://dx.doi.org/10.3390/ijms19051435

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