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Amino-Acid Network Clique Analysis of Protein Mutation Non-Additive Effects: A Case Study of Lysozyme
Optimizing amino-acid mutations in enzyme design has been a very challenging task in modern bio-industrial applications. It is well known that many successful designs often hinge on extensive correlations among mutations at different sites within the enzyme, however, the underpinning mechanism for t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983764/ https://www.ncbi.nlm.nih.gov/pubmed/29747478 http://dx.doi.org/10.3390/ijms19051427 |