Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer

Wnt/β-catenin signaling is upregulated in triple-negative breast cancer (TNBC) compared to other breast cancer subtypes and normal tissues. Current Wnt/β-catenin inhibitors, such as niclosamide, target the pathway nonspecifically and exhibit poor pharmacokinetics/pharmacodynamics in vivo. Niclosamid...

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Detalles Bibliográficos
Autores principales: Gangrade, Abhishek, Pathak, Vibha, Augelli-Szafran, Corinne E., Wei, Han-Xun, Oliver, Patsy, Suto, Mark, Buchsbaum, Donald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983770/
https://www.ncbi.nlm.nih.gov/pubmed/29783777
http://dx.doi.org/10.3390/ijms19051524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983770/
https://www.ncbi.nlm.nih.gov/pubmed/29783777
http://dx.doi.org/10.3390/ijms19051524

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