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Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer

Wnt/β-catenin signaling is upregulated in triple-negative breast cancer (TNBC) compared to other breast cancer subtypes and normal tissues. Current Wnt/β-catenin inhibitors, such as niclosamide, target the pathway nonspecifically and exhibit poor pharmacokinetics/pharmacodynamics in vivo. Niclosamid...

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Detalles Bibliográficos
Autores principales:	Gangrade, Abhishek, Pathak, Vibha, Augelli-Szafran, Corinne E., Wei, Han-Xun, Oliver, Patsy, Suto, Mark, Buchsbaum, Donald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983770/ https://www.ncbi.nlm.nih.gov/pubmed/29783777 http://dx.doi.org/10.3390/ijms19051524

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