Cargando…

Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression

Pyruvate kinase is known as the glycolytic enzyme catalyzing the final step in glycolysis. In mammals, two different forms of it exist, i.e., pyruvate kinase M1/2 (PKM) and pyruvate kinase L/R (PKLR). Also, PKM has two isoforms, i.e., PKM1 and PKM2. These genes have tissue-specific distribution. Nam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taniguchi, Kohei, Sugito, Nobuhiko, Shinohara, Haruka, Kuranaga, Yuki, Inomata, Yosuke, Komura, Kazumasa, Uchiyama, Kazuhisa, Akao, Yukihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983799/ https://www.ncbi.nlm.nih.gov/pubmed/29695138 http://dx.doi.org/10.3390/ijms19051276

Ejemplares similares

SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells
por: Kuranaga, Yuki, et al.
Publicado: (2018)

Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis
por: Inomata, Yosuke, et al.
Publicado: (2022)

MicroRNA‐143/Musashi‐2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer
por: Tsujino, Takuya, et al.
Publicado: (2019)

Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms
por: Taniguchi, Kohei, et al.
Publicado: (2015)

Potent antiproliferative effect of fatty‐acid derivative AIC‐47 on leukemic mice harboring BCR‐ABL mutation
por: Shinohara, Haruka, et al.
Publicado: (2019)

PTBP1‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing
por: Taniguchi, Kohei, et al.
Publicado: (2020)

Impairment of K‐Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR‐143
por: Akao, Yukihiro, et al.
Publicado: (2018)

Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase
por: Tokumaru, Yoshihisa, et al.
Publicado: (2019)

Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression
por: Yamada, Nami, et al.
Publicado: (2016)

Anti-Oncogenic gem-Dihydroperoxides Induce Apoptosis in Cancer Cells by Trapping Reactive Oxygen Species
por: Kuranaga, Yuki, et al.
Publicado: (2016)

A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells
por: Takai, Tomoaki, et al.
Publicado: (2017)

A Novel Role of Dickkopf-Related Protein 3 in Macropinocytosis in Human Bladder Cancer T24 Cells
por: Tsujimura, Nonoka, et al.
Publicado: (2016)

PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors
por: Taniguchi, Kohei, et al.
Publicado: (2016)

MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells
por: Minami, Koichiro, et al.
Publicado: (2017)

Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells
por: Sugito, Nobuhiko, et al.
Publicado: (2022)

Analysis of Extracellular Vesicles in Gastric Juice from Gastric Cancer Patients
por: Kagota, Shuji, et al.
Publicado: (2019)

PKM2 in carcinogenesis and oncotherapy
por: He, Xia, et al.
Publicado: (2017)

Synthetic MIR143-3p Suppresses Cell Growth in Rhabdomyosarcoma Cells by Interrupting RAS Pathways Including PAX3–FOXO1
por: Sugito, Nobuhiko, et al.
Publicado: (2020)

Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview
por: Matsuo, Kentaro, et al.
Publicado: (2021)

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
por: Bluemlein, Katharina, et al.
Publicado: (2011)

Uptake of MicroRNAs from Exosome-Like Nanovesicles of Edible Plant Juice by Rat Enterocytes
por: Ito, Yuko, et al.
Publicado: (2021)

Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis
por: Heishima, Kazuki, et al.
Publicado: (2021)

Targeting microRNA-145-mediated progressive phenotypes of early bladder cancer in a molecularly defined in vivo model
por: Heishima, Kazuki, et al.
Publicado: (2023)

Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo
por: Takai, Tomoaki, et al.
Publicado: (2019)

DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells
por: Tajirika, Toshihiro, et al.
Publicado: (2018)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

MicroRNA-214 and MicroRNA-126 Are Potential Biomarkers for Malignant Endothelial Proliferative Diseases
por: Heishima, Kazuki, et al.
Publicado: (2015)

Tumor Tissue MIR92a and Plasma MIRs21 and 29a as Predictive Biomarkers Associated with Clinicopathological Features and Surgical Resection in a Prospective Study on Colorectal Cancer Patients
por: Fukada, Masahiro, et al.
Publicado: (2020)

Postoperative changes in plasma miR21‐5p as a novel biomarker for colorectal cancer recurrence: A prospective study
por: Fukada, Masahiro, et al.
Publicado: (2021)

Evaluation of lymphatic flow pattern using indocyanine green fluorescence imaging in a highly metastatic mouse model
por: Yamamoto, Masashi, et al.
Publicado: (2020)

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis
por: Zahra, Kulsoom, et al.
Publicado: (2020)

MicroRNA-122 regulates docetaxel resistance of prostate cancer cells by regulating PKM2
por: Zhu, Zhirong, et al.
Publicado: (2020)

Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative
por: Kumazaki, Minami, et al.
Publicado: (2015)

MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis
por: Heishima, Kazuki, et al.
Publicado: (2015)

MicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma
por: Xu, Qiuran, et al.
Publicado: (2021)

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the K(ATP) channel
por: Foster, Hannah R, et al.
Publicado: (2022)

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers
por: Desai, Shruti, et al.
Publicado: (2013)

[Retracted] MicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma
por: Xu, Qiuran, et al.
Publicado: (2023)

Understanding of cell death induced by the constituents of Taxus yunnanensis wood
por: Akao, Yukihiro, et al.
Publicado: (2022)

MiR‐133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle‐splicer polypyrimidine tract‐binding protein 1
por: Sugiyama, Taro, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o27qb6c8m2aagt8qsgs5l7i7kn